Substance
ID:348034
Names and Identifiers
IUPAC name
4-amino-N-(5,6-dimethoxypyrimidin-4-yl)benzene-1-sulfonamide
IUPAC Traditional name
sulfadoxine
Synonyms
Sulfadoxin磺胺多辛
Registration numbers
EC Number
Beilstein Number
CAS Number
MDL Number
PubChem SID
Properties
Product Information
Purity
≥95% (TLC)
Empirical Formula (Hill Notation)
C12H14N4O4S
Safety Information
MSDS Link
Safety Statements
26
RTECS
DA9500000
GHS Signal Word
Warning
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
GHS Hazard statements
H315-H319-H335
GHS Precautionary statements
P261-P305+P351+P338
German water hazard class
2
GHS Pictograms
Acute toxicity (oral, dermal, inhalation), category 4
Skin irritation, category 2
Eye irritation, category 2
Skin sensitisation, category 1
Specific Target Organ Toxicity – Single exposure, category 3
Risk Statements
36/37/38
European Hazard Symbols
Irritant (Xi)Molecule Details
Application
Sulfadoxine is a sulfonamide antibiotic used in combination with pyrimethamine for the treatment or prevention of malaria. It is also used to treat various infections in livestock. Sulfadoxine and pyrimethamine is indicated for the treatment of Plasmodium falciparum malaria in patients where chloroquine resistance is suspected1. It is used to study infections caused by Toxoplasma gondii2 and has been used to prevent infections after surgery during animal studies3.
Biochem/physiol Actions
Sulfadoxine is a sulfonamide antibacterial that inhibits dihydropteroate synthase (DHPS), an enzyme that transforms 4-aminobenzoic acid (PABA) in the synthesis of dihydropteroic acid. This enzyme is also a component of the folate metabolic pathway and is upstream of dihydrofolate reductase (DHFR).
Sulfadoxine is a sulfonamide antibiotic used in combination with pyrimethamine for the treatment or prevention of malaria. It is also used to treat various infections in livestock. Sulfadoxine and pyrimethamine is indicated for the treatment of Plasmodium falciparum malaria in patients where chloroquine resistance is suspected1. It is used to study infections caused by Toxoplasma gondii2 and has been used to prevent infections after surgery during animal studies3.
Biochem/physiol Actions
Sulfadoxine is a sulfonamide antibacterial that inhibits dihydropteroate synthase (DHPS), an enzyme that transforms 4-aminobenzoic acid (PABA) in the synthesis of dihydropteroic acid. This enzyme is also a component of the folate metabolic pathway and is upstream of dihydrofolate reductase (DHFR).
Molecular Spectra
No Data Available
Click here to submit data
References
No Data Available
Click here to submit data