Substance
ID:347140
Names and Identifiers
IUPAC name
2-bromo-2-chloro-1,1,1-trifluoroethane
IUPAC Traditional name
halothane
Synonyms
Halothane2-Bromo-2-chloro-1,1,1-trifluoroethane
Registration numbers
Beilstein Number
EC Number
CAS Number
MDL Number
PubChem SID
Properties
Safety Information
Personal Protective Equipment
Eyeshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US)
Safety Statements
53-23-26-36/37-45
GHS Pictograms
Respiratory sensitization, category 1
Germ cell mutagenicity, categories 1A,1B,2
Carcinogenicity, categories 1A,1B,2
Reproductive toxicity, categories 1A,1B,2
Specific Target Organ Toxicity – Single exposure, categories 1,2
Specific Target Organ Toxicity – Repeated exposure, categories 1,2
Aspiration Hazard, category 1
Corrosive to metals, category 1
Skin corrosion, categories 1A,1B,1C
Serious eye damage, category 1
Acute toxicity (oral, dermal, inhalation), category 4
Skin irritation, category 2
Eye irritation, category 2
Skin sensitisation, category 1
Specific Target Organ Toxicity – Single exposure, category 3
GHS Signal Word
Danger
GHS Precautionary statements
P201-P261-P280-P305+P351+P338-P308+P313
MSDS Link
Risk Statements
61-37/38-41
RTECS
KH6550000
German water hazard class
3
GHS Hazard statements
H315-H318-H335-H360
European Hazard Symbols
Toxic (T)Product Information
Purity
≥99%
Linear Formula
BrCH(Cl)CF3
Contains
0.01% thymol as stabilizer
Pharmacology Properties
Gene Information
human ... ATP5D(513), GLRA1(2741), GRIA1(2890), KCNN4(3783)
Physical Property
Boiling Point
50.2 °C(lit.)
Density
1.872 g/mL at 25 °C(lit.)
Refractive Index
n20/D 1.369(lit.)
Vapor Pressure
4.5 psi ( 20 °C)
Molecule Details
Packaging
125, 250 mL in glass bottle
Application
2-Bromo-2-chloro-1,1,1-trifluoroethane, or halothane, has been used in a study that combined molecular simulations with free energy simulations to study solvation of halothane in polarizable water and methanol. Halothane has also been used in a study to investigate the interaction of anesthetics with the Rho GTPase regulator Rho GDP dissociation inhibitor.
Biochem/physiol Actions
Inhalation anesthetic. In an effect believed to be independent of anesthesia, halothane inhibits synthesis of 5-hydroxytryptamine in brain tissue, probably at the tryptophan hydroxylase step.1
125, 250 mL in glass bottle
Application
2-Bromo-2-chloro-1,1,1-trifluoroethane, or halothane, has been used in a study that combined molecular simulations with free energy simulations to study solvation of halothane in polarizable water and methanol. Halothane has also been used in a study to investigate the interaction of anesthetics with the Rho GTPase regulator Rho GDP dissociation inhibitor.
Biochem/physiol Actions
Inhalation anesthetic. In an effect believed to be independent of anesthesia, halothane inhibits synthesis of 5-hydroxytryptamine in brain tissue, probably at the tryptophan hydroxylase step.1
Molecular Spectra
No Data Available
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References
No Data Available
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