Substance
ID:346890
Names and Identifiers
Synonyms
对-[(2,4-二氨基喋啶-6)-N-甲基甲氨基]苯甲酰谷氨酸 水合物甲氨蝶呤氟安定 水合物L-氨甲喋呤 水合物氨甲喋呤 水合物甲氨蝶呤 水合物MethotrexateMTX 水合物氨甲叶酸 水合物L-Amethopterin hydrateMTX hydrateMethotrexate hydrate4-Amino-10-methylfolic acid hydrateL-4-Amino-N10-methylpteroylglutamic acid hydrateAntifolan hydrateMethylaminopterin hydrate
IUPAC Traditional name
hydrate methotrexate
IUPAC name
(2S)-2-[(4-{[(2,4-diaminopteridin-6-yl)methyl](methyl)amino}phenyl)formamido]pentanedioic acid hydrate
Properties
Safety Information
GHS Signal Word
Danger
Packing Group
3
German water hazard class
3
Risk Statements
61-25-36/38
RID/ADR
UN 1544 6.1/PG 3
European Hazard Symbols
Toxic (T)GHS Precautionary statements
P201-P301+P310-P305+P351+P338-P308+P313
Safety Statements
53-26-36/37-45
UN Number
1544
GHS Pictograms
Acute toxicity (oral, dermal, inhalation), categories 1,2,3
Respiratory sensitization, category 1
Germ cell mutagenicity, categories 1A,1B,2
Carcinogenicity, categories 1A,1B,2
Reproductive toxicity, categories 1A,1B,2
Specific Target Organ Toxicity – Single exposure, categories 1,2
Specific Target Organ Toxicity – Repeated exposure, categories 1,2
Aspiration Hazard, category 1
GHS Hazard statements
H301-H315-H319-H360
Personal Protective Equipment
Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
MSDS Link
Storage Temperature
-20°C
Hazard Class
6.1
RTECS
MA1225000
Product Information
Empirical Formula (Hill Notation)
C20H22N8O5 · xH2O
Suitability
meets EP, USP testing specifications
Molecule Details
Application
Potent inhibitor of dihydrofolate reductase1 and agent for antitumor studies.2,3 Use to inhibit dihydrofolate reductase in DHFR-based protein expression systems. Also effective in treatment of pyrimethamine-resistant Plasmodium vivax malaria parasites.4
Potent inhibitor of dihydrofolate reductase1 and agent for antitumor studies.2,3 Use to inhibit dihydrofolate reductase in DHFR-based protein expression systems. Also shows immunosuppressive effects in, e.g., rheumatoid arthritis.
Potent inhibitor of dihydrofolate reductase1 and agent for antitumor studies.2,3 Use to inhibit dihydrofolate reductase in DHFR-based protein expression systems. Also effective in treatment of pyrimethamine-resistant Plasmodium vivax malaria parasites.4
Potent inhibitor of dihydrofolate reductase1 and agent for antitumor studies.2,3 Use to inhibit dihydrofolate reductase in DHFR-based protein expression systems. Also shows immunosuppressive effects in, e.g., rheumatoid arthritis.
Molecular Spectra
No Data Available
Click here to submit data
References
No Data Available
Click here to submit data