Substance
ID:345785
Names and Identifiers
IUPAC name
trimethyl(trifluoromethyl)silane
IUPAC Traditional name
trifluoromethyltrimethylsilane
Synonyms
TFMTMSTrifluoromethyltrimethylsilaneRuppert′s reagentTrimethyl(trifluoromethyl)silane solution三氟甲基三甲基硅烷 溶液Ruppert-Prakash reagent(Trifluoromethyl)trimethylsilane
Registration numbers
CAS Number
MDL Number
Beilstein Number
PubChem SID
Properties
Product Information
Linear Formula
(CH3)3SiCF3
Concentration
~2.0 M in THF
Safety Information
European Hazard Symbols
Irritant (Xi)
Flammable (F)MSDS Link
Risk Statements
11-19-36/37
UN Number
1993
GHS Signal Word
Danger
Hazard Class
3
GHS Pictograms
Flammable gases, category 1
Flammable aerosols, categories 1,2
Flammable liquids, categories 1,2,3
Self-reactive substances and mixtures, Types B,C,D,E,F
Pyrophoric liquids, category 1
Pyrophoric solids, category 1
Self-heating substances and mixtures
Substances and mixtures, which in contact with water, emit flammable gases, categories 1,2,3
Organic peroxides, Types B,C,D,E,F
Acute toxicity (oral, dermal, inhalation), category 4
Skin irritation, category 2
Eye irritation, category 2
Skin sensitisation, category 1
Specific Target Organ Toxicity – Single exposure, category 3
Supplemental Hazard Statements
May form explosive peroxides.
German water hazard class
3
GHS Hazard statements
H225-H319-H335
RID/ADR
UN 1993 3/PG 2
Safety Statements
16-26
Personal Protective Equipment
Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter
Packing Group
2
GHS Precautionary statements
P210-P261-P305+P351+P338
Physical Property
Refractive Index
n20/D 1.386
Density
0.91 g/mL at 20 °C
Flash Point
1.4 °F
-17 °C
Molecule Details
Packaging
10, 50 mL in glass bottle
Application
Reactant for:
• Silver-mediated C-H trifluoromethylation of arenes1
• Preparation of trifluoromethyl ketone analog of L-arginine having contrasting inhibitory activity against human arginase I and histone deacetylase 82
• Organocatalyzed regio- and enantioselective allylic trifluoromethylation of Morita-Baylis-Hillman adducts3
• Palladium-catalyzed oxidative trifluoromethylation of indoles4
• Preparation of 5-HT1A antagonists5
• Used as difluorocarbene source6
10, 50 mL in glass bottle
Application
Reactant for:
• Silver-mediated C-H trifluoromethylation of arenes1
• Preparation of trifluoromethyl ketone analog of L-arginine having contrasting inhibitory activity against human arginase I and histone deacetylase 82
• Organocatalyzed regio- and enantioselective allylic trifluoromethylation of Morita-Baylis-Hillman adducts3
• Palladium-catalyzed oxidative trifluoromethylation of indoles4
• Preparation of 5-HT1A antagonists5
• Used as difluorocarbene source6
Molecular Spectra
No Data Available
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References
No Data Available
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