Substance
ID:339
Names and Identifiers
IUPAC name
(6R,7R)-3-[(acetyloxy)methyl]-8-oxo-7-[2-(thiophen-2-yl)acetamido]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
Brand Name
Averon-1CemastinKeflinSeffinCoaxin
Synonyms
Cephalothin SodiumCephalotinCLSCefalotinCefalotina [INN-Spanish]CephalothinCefalothinCefalotinum [INN-Latin]CephalothinumCefalotine [INN-French]
IUPAC Traditional name
cefalotin
Properties
Physical Property
Hydrophobicity(logP)
-0.2
Solubility
158 mg/L
Molecule Details
Drug Groups
approved
Description
A cephalosporin antibiotic. [PubChem]
Indication
Used to prevent infection during surgery and to treat many kinds of infections of the blood, bone or joints, respiratory tract, skin, and urinary tract.
Pharmacology
Cefalotin (INN) or cephalothin (USAN) is a semisynthetic first generation cephalosporin having a broad spectrum of antibiotic activity that is administered parenterally.
Toxicity
Rat intravenous LD50 is 4000 mg/kg.
Affected Organisms
Enteric bacteria and other eubacteria
Biotransformation
Metabolized to a less active desacetyl metabolite, although 50-75% of the drug is eliminated unchanged in the urine.
Half Life
30 minutes
Protein Binding
65-80%
External Links
Molecular Spectra
No Data Available
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References
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