Substance
ID:334613
Names and Identifiers
IUPAC Traditional name
pyridine hydrofluoride
IUPAC name
pyridine hydrofluoride
Synonyms
Pyridinium poly(hydrogen fluoride)Pyridine hydrofluorideHydrogen fluoride pyridine吡啶氢氟酸盐氟化氢吡啶PPHFHF-PyridineOlah′s reagentPyridinium polybifluoridePoly(pyridine fluoride)HF-吡啶
Registration numbers
MDL Number
CAS Number
Beilstein Number
PubChem SID
Properties
Safety Information
GHS Precautionary statements
P260-P264-P280-P284-P301+P310-P302+P350
GHS Hazard statements
H300-H310-H314-H330
Risk Statements
26/27/28-35
Packing Group
1
German water hazard class
3
Safety Statements
26-28-36/37/39-45
GHS Signal Word
Danger
GHS Pictograms
Corrosive to metals, category 1
Skin corrosion, categories 1A,1B,1C
Serious eye damage, category 1
Acute toxicity (oral, dermal, inhalation), categories 1,2,3
MSDS Link
RID/ADR
UN 1790 8/PG 1
Hazard Class
8
European Hazard Symbols
Toxic (T)Personal Protective Equipment
Faceshields, full-face respirator (US), Gloves, Goggles, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter
Storage Temperature
-20°C
UN Number
1790
Product Information
Linear Formula
C5H5N · (HF)x
Compostion
pyridine, ~30%
hydrogen fluoride, ~70%
Physical Property
Density
1.1 g/mL at 20 °C(lit.)
Molecule Details
General description
May contain or form low levels of calcium fluoride during storage. Presence of this does not impact the specification values.
Packaging
25, 100 g in poly bottle
Application
Convenient form of anhydrous HF, stable up to 50°C. Has been used for the preparation of β-fluoroamines from amino alcohols and for the fluorination of acetylenes.1,2Used together with hypervalent iodine(III) reagents for ipso-fluorination of para-substituted phenols providing cyclohexadienones.3 Employed with Selectfluor™ (Catalog No. 439479) for geminal fluorination of 2,2-diaryl-1,3-dithiolanes.4
Reactant for preparation of:
• Epimers of shikimic acid with the features of fucosylated glycans via zinc-mediated reductive ring opening followed by a Barbier reaction
• Vaccinia H1-related (VHR) phosphatase inhibitor with a nonacidic phosphate-mimicking core structure
• Candidates for nucleic acid drugs
• ω-substituted gem-difluoroalkanes by oxidative desulfurization-difluorinationReagent for:
• Halofluorination reactions
Legal Information
Selectfluor is a registered trademark of Air Products & Chemicals, Inc.
Sure/Pac is a trademark of Sigma-Aldrich Co. LLC
May contain or form low levels of calcium fluoride during storage. Presence of this does not impact the specification values.
Packaging
25, 100 g in poly bottle
Application
Convenient form of anhydrous HF, stable up to 50°C. Has been used for the preparation of β-fluoroamines from amino alcohols and for the fluorination of acetylenes.1,2Used together with hypervalent iodine(III) reagents for ipso-fluorination of para-substituted phenols providing cyclohexadienones.3 Employed with Selectfluor™ (Catalog No. 439479) for geminal fluorination of 2,2-diaryl-1,3-dithiolanes.4
Reactant for preparation of:
• Epimers of shikimic acid with the features of fucosylated glycans via zinc-mediated reductive ring opening followed by a Barbier reaction
• Vaccinia H1-related (VHR) phosphatase inhibitor with a nonacidic phosphate-mimicking core structure
• Candidates for nucleic acid drugs
• ω-substituted gem-difluoroalkanes by oxidative desulfurization-difluorinationReagent for:
• Halofluorination reactions
Legal Information
Selectfluor is a registered trademark of Air Products & Chemicals, Inc.
Sure/Pac is a trademark of Sigma-Aldrich Co. LLC
Molecular Spectra
No Data Available
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References
No Data Available
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