Substance
ID:329763
Names and Identifiers
IUPAC Traditional name
tryptoline
IUPAC name
1H,2H,3H,4H,9H-pyrido[3,4-b]indole
Synonyms
NoreleagnineTetrahydronorharmanTetrahydronorharmane1,2,3,4-Tetrahydro-9H-pyrido[3,4-b]indole2,3,4,9-四氢-1H-吡啶并(3,4-b)吲哚1,2,3,4-四氢-9H-吡啶并[3,4-b]吲哚Tryptoline1,2,3,4-四氢-β-咔啉THBC
Properties
Safety Information
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
European Hazard Symbols
Irritant (Xi)GHS Precautionary statements
P261-P305+P351+P338
Safety Statements
26-36
German water hazard class
3
GHS Pictograms
Acute toxicity (oral, dermal, inhalation), category 4
Skin irritation, category 2
Eye irritation, category 2
Skin sensitisation, category 1
Specific Target Organ Toxicity – Single exposure, category 3
GHS Signal Word
Warning
GHS Hazard statements
H315-H319-H335
MSDS Link
Risk Statements
36/37/38
Product Information
Purity
98%
Empirical Formula (Hill Notation)
C11H12N2
Pharmacology Properties
Gene Information
rat ... Htr2a(29595), Htr2c(25187)
Physical Property
Melting Point
206-208 °C(lit.)
Molecule Details
Packaging
1, 5 g in glass bottle
Application
• Reactant for synthesis of the indolyl-β-carboline alkaloid eudistomin U via IBX mediated room temperature oxidative aromatization1
• Reactant for preparation of neuroprotective HDAC6 inhibitors2
• Reactant for preparation of aminofuranopyrimidines as EGFR and Aurora A kinase inhibitors3
• Reactant for preparation of inhibitors of CDK44
• Reactant for preparation of tetrahydrocarboline derivatives of as human 5-HT5A receptor ligands5
• Reactant for preparation of 5-(diaminomethyl)-2,4-aminopyrimidines as dihydrofolate reductase inhibitors and antibacterial agents6
Employed in alkaloid synthesis and in studies on neurodegenerative diseases.
Other Notes
Tandem Mass Spectrometry data independently generated by Scripps Center for Metabolomics is available to view or download in PDF. 300764.pdf Tested metabolites are featured on Scripps Center for Metabolomics METLIN Metabolite Database. To learn more, visit sigma.com/metlin.
1, 5 g in glass bottle
Application
• Reactant for synthesis of the indolyl-β-carboline alkaloid eudistomin U via IBX mediated room temperature oxidative aromatization1
• Reactant for preparation of neuroprotective HDAC6 inhibitors2
• Reactant for preparation of aminofuranopyrimidines as EGFR and Aurora A kinase inhibitors3
• Reactant for preparation of inhibitors of CDK44
• Reactant for preparation of tetrahydrocarboline derivatives of as human 5-HT5A receptor ligands5
• Reactant for preparation of 5-(diaminomethyl)-2,4-aminopyrimidines as dihydrofolate reductase inhibitors and antibacterial agents6
Employed in alkaloid synthesis and in studies on neurodegenerative diseases.
Other Notes
Tandem Mass Spectrometry data independently generated by Scripps Center for Metabolomics is available to view or download in PDF. 300764.pdf Tested metabolites are featured on Scripps Center for Metabolomics METLIN Metabolite Database. To learn more, visit sigma.com/metlin.
Molecular Spectra
No Data Available
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References
No Data Available
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