Substance
ID:324626
Names and Identifiers
IUPAC name
trimethyl(trifluoromethyl)silane
IUPAC Traditional name
trifluoromethyltrimethylsilane
Synonyms
TFMTMSTrifluoromethyltrimethylsilaneRuppert′s reagentTrimethyl(trifluoromethyl)silane solution三氟甲基三甲基硅烷 溶液Ruppert-Prakash reagent(Trifluoromethyl)trimethylsilane
Registration numbers
CAS Number
MDL Number
Beilstein Number
PubChem SID
Properties
Safety Information
Risk Statements
11-19-36/37
Hazard Class
3
Safety Statements
16-26
German water hazard class
3
GHS Pictograms
Acute toxicity (oral, dermal, inhalation), category 4
Skin irritation, category 2
Eye irritation, category 2
Skin sensitisation, category 1
Specific Target Organ Toxicity – Single exposure, category 3
Flammable gases, category 1
Flammable aerosols, categories 1,2
Flammable liquids, categories 1,2,3
Self-reactive substances and mixtures, Types B,C,D,E,F
Pyrophoric liquids, category 1
Pyrophoric solids, category 1
Self-heating substances and mixtures
Substances and mixtures, which in contact with water, emit flammable gases, categories 1,2,3
Organic peroxides, Types B,C,D,E,F
GHS Signal Word
Danger
European Hazard Symbols
Flammable (F)
Irritant (Xi)MSDS Link
Supplemental Hazard Statements
May form explosive peroxides.
GHS Precautionary statements
P210-P261-P305+P351+P338
UN Number
1993
GHS Hazard statements
H225-H319-H335
RID/ADR
UN 1993 3/PG 2
Packing Group
2
Physical Property
Flash Point
-17 °C
1.4 °F
Vapor Pressure
2.8 psi ( 20 °C)
10.98 psi ( 55 °C)
Density
0.895 g/mL at 25 °C
Boiling Point
40 °C
Product Information
Concentration
0.5 M in THF
Linear Formula
(CH3)3SiCF3
Molecule Details
Application
Nucleophilic addition of the trifluoromethyl group to aldehydes and ketones.7
Reactant for:
• Silver-mediated C-H trifluoromethylation of arenes1
• Preparation of trifluoromethyl ketone analog of L-arginine having contrasting inhibitory activity against human arginase I and histone deacetylase 82
• Organocatalyzed regio- and enantioselective allylic trifluoromethylation of Morita-Baylis-Hillman adducts3
• Palladium-catalyzed oxidative trifluoromethylation of indoles4
• Preparation of 5-HT1A antagonists5
• Used as difluorocarbene source6
Packaging
25 mL in Sure/Seal™
5 mL in glass bottle
Nucleophilic addition of the trifluoromethyl group to aldehydes and ketones.7
Reactant for:
• Silver-mediated C-H trifluoromethylation of arenes1
• Preparation of trifluoromethyl ketone analog of L-arginine having contrasting inhibitory activity against human arginase I and histone deacetylase 82
• Organocatalyzed regio- and enantioselective allylic trifluoromethylation of Morita-Baylis-Hillman adducts3
• Palladium-catalyzed oxidative trifluoromethylation of indoles4
• Preparation of 5-HT1A antagonists5
• Used as difluorocarbene source6
Packaging
25 mL in Sure/Seal™
5 mL in glass bottle
Molecular Spectra
No Data Available
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References
No Data Available
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