Substance
ID:313816
Names and Identifiers
IUPAC Traditional name
{2-[4-(1,2-diphenylbut-1-en-1-yl)phenoxy]ethyl}dimethylamine
IUPAC name
{2-[4-(1,2-diphenylbut-1-en-1-yl)phenoxy]ethyl}dimethylamine
Synonyms
trans-2-[4-(1,2-Diphenyl-1-butenyl)phenoxy]-N,N-dimethylethylamine(Z)-1-(对二甲基氨基乙氧基苯基)-1,2-二苯基-1-丁烯(Z)-2-[4-(1,2-二苯基-1-丁烯)苯氧基]-N,N-二甲基乙胺(Z)-1-(p-Dimethylaminoethoxyphenyl)-1,2-diphenyl-1-butene他莫昔芬Tamoxifen
Properties
Product Information
Purity
96%
Linear Formula
C6H5C(C2H5)=C(C6H5)C6H4OCH2CH2N(CH3)2
Pharmacology Properties
Gene Information
human ... ESR1(2099)
Safety Information
GHS Pictograms
Respiratory sensitization, category 1
Germ cell mutagenicity, categories 1A,1B,2
Carcinogenicity, categories 1A,1B,2
Reproductive toxicity, categories 1A,1B,2
Specific Target Organ Toxicity – Single exposure, categories 1,2
Specific Target Organ Toxicity – Repeated exposure, categories 1,2
Aspiration Hazard, category 1
European Hazard Symbols
Toxic (T)MSDS Link
GHS Signal Word
Danger
Safety Statements
53-45
Risk Statements
45-60-61-64
GHS Hazard statements
H350-H360-H362
Personal Protective Equipment
Eyeshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
RTECS
KR5919600
GHS Precautionary statements
P201-P263-P308+P313
German water hazard class
3
Physical Property
Melting Point
97-98 °C(lit.)
Molecule Details
Biochem/physiol Actions
Protein kinase C inhibitor. Induces apoptosis in human malignant glioma cell lines. Tamoxifen and its metabolite 4-hydroxytamoxifen are selective estrogen response modifiers (SERMs) that act as estrogen antagonists in mammary gland. Blocks estradiol-stimulated VEGF production in breast tumor cells.
Protein kinase C inhibitor. Induces apoptosis in human malignant glioma cell lines. Tamoxifen and its metabolite 4-hydroxytamoxifen are selective estrogen response modifiers (SERMs) that act as estrogen antagonists in mammary gland. Blocks estradiol-stimulated VEGF production in breast tumor cells.
Molecular Spectra
No Data Available
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References
No Data Available
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