Substance
ID:312785
Names and Identifiers
IUPAC Traditional name
benzamidine hydrate hydrochloride
IUPAC name
benzenecarboximidamide hydrate hydrochloride
Synonyms
Benzenecarboximidamide hydrochlorideBenzamidinium chlorideAmidinobenzene hydrochlorideBenzamidine hydrochloride hydrate苯甲脒 盐酸盐 水合物苄脒 盐酸盐盐酸苄脒
Registration numbers
EC Number
CAS Number
MDL Number
Beilstein Number
Properties
Physical Property
Melting Point
86-88 °C(lit.)
Safety Information
GHS Pictograms
Acute toxicity (oral, dermal, inhalation), category 4
Skin irritation, category 2
Eye irritation, category 2
Skin sensitisation, category 1
Specific Target Organ Toxicity – Single exposure, category 3
GHS Precautionary statements
P261-P305+P351+P338
German water hazard class
3
Safety Statements
26-36
European Hazard Symbols
Irritant (Xi)Risk Statements
36/37/38
GHS Signal Word
Warning
GHS Hazard statements
H315-H319-H335
MSDS Link
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Product Information
Purity
97%
Linear Formula
C6H5C(=NH)NH2 · HCl · xH2O
Molecule Details
Application
Used in a "ne-pot"preparation of imidazolines from cyclic sulfates of vicinal diols.1
Biochem/physiol Actions
Benzamidine HCl is a reversible inhibitor of trypsin, trypsin-like enzymes, and serine proteases. A concentration of approximately 1 mM is used for general protease inhibition. To inhibit proteases from yeast, a range of 0.5 to 4.0 mM is used and it is for the most part interchangeable with pepstatin A.In addition to being a strong competitive inhibitor of trypsin, benzamidine HCl has been also shown to be a strong competitive inhibitor of thrombin and plasmin. It was also found to be as effective as aprotinin in the prevention of glucagon degradation in human plasma.
Peptidase inhibitor.
Preparation Note
Benzamidine HCl is soluble in water and alcohol. Solubility testing in water at a concentration of 50 mg/ml yields a clear solution with heating. Benzamidine HCl is sensitive to oxidation. It is recommended to prepare solutions fresh each time in degassed water prior to use. However, frozen aliquots stored under inert gas, to exclude air, may be stable for a short time. Insufficient information is available to assess the shelf-life of a frozen solution.
Used in a "ne-pot"preparation of imidazolines from cyclic sulfates of vicinal diols.1
Biochem/physiol Actions
Benzamidine HCl is a reversible inhibitor of trypsin, trypsin-like enzymes, and serine proteases. A concentration of approximately 1 mM is used for general protease inhibition. To inhibit proteases from yeast, a range of 0.5 to 4.0 mM is used and it is for the most part interchangeable with pepstatin A.In addition to being a strong competitive inhibitor of trypsin, benzamidine HCl has been also shown to be a strong competitive inhibitor of thrombin and plasmin. It was also found to be as effective as aprotinin in the prevention of glucagon degradation in human plasma.
Peptidase inhibitor.
Preparation Note
Benzamidine HCl is soluble in water and alcohol. Solubility testing in water at a concentration of 50 mg/ml yields a clear solution with heating. Benzamidine HCl is sensitive to oxidation. It is recommended to prepare solutions fresh each time in degassed water prior to use. However, frozen aliquots stored under inert gas, to exclude air, may be stable for a short time. Insufficient information is available to assess the shelf-life of a frozen solution.
Molecular Spectra
No Data Available
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References
No Data Available
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