Substance
ID:311416
Names and Identifiers
IUPAC Traditional name
hydroxyurea
IUPAC name
hydroxyurea
Synonyms
Hydroxycarbamide羟基脲Hydroxyurea
Registration numbers
CAS Number
MDL Number
Beilstein Number
EC Number
Properties
Safety Information
GHS Signal Word
Danger
European Hazard Symbols
Toxic (T)MSDS Link
Safety Statements
53-36/37-45
RTECS
YT4900000
GHS Precautionary statements
P201-P281-P308+P313
Risk Statements
46-63
GHS Pictograms
Respiratory sensitization, category 1
Germ cell mutagenicity, categories 1A,1B,2
Carcinogenicity, categories 1A,1B,2
Reproductive toxicity, categories 1A,1B,2
Specific Target Organ Toxicity – Single exposure, categories 1,2
Specific Target Organ Toxicity – Repeated exposure, categories 1,2
Aspiration Hazard, category 1
GHS Hazard statements
H340-H361
German water hazard class
3
Personal Protective Equipment
Eyeshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
Product Information
Linear Formula
NH2CONHOH
Purity
98%
Molecule Details
Application
Inhibitor of DNA synthesis.
Biochem/physiol Actions
Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase.
Inhibitor of DNA synthesis.
Biochem/physiol Actions
Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase.
Molecular Spectra
No Data Available
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References
No Data Available
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