Substance
ID:310609
Names and Identifiers
IUPAC Traditional name
flurbiprofen
IUPAC name
2-(3-fluoro-4-phenylphenyl)propanoic acid
Synonyms
Flurbiprofen氟比洛芬(±)-2-Fluoro-α-methyl-4-biphenylacetic acid(±)-2-氟-α-甲基-4-联苯基乙酸L-790,330
Properties
Safety Information
GHS Pictograms
Acute toxicity (oral, dermal, inhalation), categories 1,2,3
GHS Signal Word
Danger
European Hazard Symbols
Toxic (T)RID/ADR
UN 2811 6.1/PG 3
MSDS Link
GHS Precautionary statements
P301+P310
RTECS
DU8341000
Safety Statements
36/37/39-45
Packing Group
3
Personal Protective Equipment
Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
Hazard Class
6.1
German water hazard class
3
GHS Hazard statements
H301
UN Number
2811
Risk Statements
25
Product Information
Linear Formula
C6H5C6H3(F)CH(CH3)CO2H
Purity
97%
Physical Property
Melting Point
110-112 °C(lit.)
Molecule Details
Biochem/physiol Actions
Fluibiprofen is a cyclooxygenase (COX) inhibitor, which is an enzyme responsible for the conversion of arachidonic acid to prostaglandin G2 (PGG2) and PGG2 to prostaglandin H2 (PGH2) in the prostaglandin synthesis pathway. This decreases the prostaglandins which cause inflammation, pain, swelling and fever. Flurbiprofen inhibits the activity of both COX-1 and -2. The S enantiomer inhibits prostaglandin synthesis and has both anti-inflammatory and analgesic activity, while the R enantiomer does not inhibit prostaglandin synthesis and displays only analgesic activity.
Fluibiprofen is a cyclooxygenase (COX) inhibitor, which is an enzyme responsible for the conversion of arachidonic acid to prostaglandin G2 (PGG2) and PGG2 to prostaglandin H2 (PGH2) in the prostaglandin synthesis pathway. This decreases the prostaglandins which cause inflammation, pain, swelling and fever. Flurbiprofen inhibits the activity of both COX-1 and -2. The S enantiomer inhibits prostaglandin synthesis and has both anti-inflammatory and analgesic activity, while the R enantiomer does not inhibit prostaglandin synthesis and displays only analgesic activity.
Molecular Spectra
No Data Available
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References
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