Substance
ID:294
Names and Identifiers
IUPAC Traditional name
carbamyl-choline
IUPAC name
2-(trimethylazaniumyl)ethyl carbamate
Brand Name
DorylKarbacholKarbamoylcholin chloridCarbachol chlorideCarbaminoylcholine chlorideCarbamylcholine chlorideCarbastat intraocularCarbocholinCholine chloride, carbamoyl-Isopto CarbacholLentineMistura CP. V. CarbacholRilentolCholine chlorine carbamateColetylMorylCarbacholinCarbacolinaCarbachol hydrochlorideCarbaminocholine chlorideCarbamoylcholine-hydrochlorideCarbopticCarbylCholine chloride carbamateMiostatVasoperifCBCarbachol USP27CarbocholineCarcholinCholine carbamate chlorideCholine, chloride, carbamateJestrylLentinCarbacholineCarbacholine chlorideCarbamiotinCarbamoylcholine chlorideCarbastatCarbochol
Synonyms
Carbachol
Registration numbers
CAS Number
Properties
Physical Property
Solubility
1 g/ml
Hydrophobicity(logP)
-3.78
Molecule Details
Drug Groups
approved
Description
A slowly hydrolyzed cholinergic agonist that acts at both muscarinic and nicotinic receptors. [PubChem]
Indication
Primarily used in the treatment of glaucoma, but is also used during ophthalmic surgery.
Pharmacology
Carbachol is a potent cholinergic (parasympathomimetic) agent which produces constriction of the iris and ciliary body resulting in reduction in intraocular pressure. The exact mechanism by which carbachol lowers intraocular pressure is not precisely known. In the cat and rat, carbachol is well-known for its ability to induce rapid eye movement (REM) sleep when microinjected into the pontine reticular formation. Carbachol elicits this REM sleep-like state via activation of postsynaptic muscarinic cholinergic receptors (mAChRs).
Toxicity
Oral, mouse: LD50 = 15 mg/kg; Oral, rat: LD50 = 40 mg/kg.
Affected Organisms
Humans and other mammals
Absorption
Not well absorbed in the gastro-intestinal tract, and does not cross the blood-brain barrier.
External Links
Molecular Spectra
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References
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