Substance
ID:2809
Names and Identifiers
Synonyms
pyrimidin-2-one beta-ribofuranosidePyrimidin-2-one ribonucleosidePyrimidin-2-one beta-D-ribofuranoside1-beta-D-ribofuranosylpyrimidin-2(1H)-oneDHZ1-beta-D-ribofuranosyl-2(1H)-pyrimidinoneZebularine
IUPAC Traditional name
zebularine
IUPAC name
1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,2-dihydropyrimidin-2-one
Properties
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Molecule Details
Drug Groups
experimental
Description
A chemically stable, cytidine analog that displays anti-tumor properties. Acts as a transition state analog inhibitor of cytidine deaminase by binding to the active size as covalent hydrates. Also shown to inhibit DNA methylation and tumor growth both in vitro and in vivo.
Molecular Spectra
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References
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