Substance
ID:274
Names and Identifiers
IUPAC Traditional name
@sulpiride
IUPAC name
N-[(1-ethylpyrrolidin-2-yl)methyl]-2-methoxy-5-sulfamoylbenzamide
Synonyms
SulpirideLevosulpirideLevosulpiride [INN]Levosulpiridum [INN-Latin]Sulpiridum [INN-Latin]SulpiridLevosulpirida [INN-Spanish]Sulpirida [INN-Spanish]Sulpyrid
Brand Name
AbilitChampionylDobrenPyrkapplStamonevrolSursumidSynedilValiremZemorconFidelanLevopraidNorestranOmirylOzoderpinPyrikapplAlimoralCoolspanEquilidFardalanEnimonLisopirideMeresaMirbanilNufarolTrilanDarletonDresentEclorionOmperanPsicocenSulprideSupriumIsnamideKylistroLevobrenMiradolMisulvanNeogamaCalmoflorineDesmenatDogmatylDolmatilEglonilEusulpidSernevinSplotinSulpitilAiglonylDogmatilEglonylGuastilMariastelNormumRestful
Properties
Physical Property
Solubility
2280 mg/L
Hydrophobicity(logP)
0.6
Molecule Details
Drug Groups
approved
Description
A dopamine D2-receptor antagonist. It has been used therapeutically as an antidepressant, antipsychotic, and as a digestive aid. (From Merck Index, 11th ed)
Indication
Sulpiride is indicated for the treatment of schizophrenia.
Pharmacology
Sulpiride is a substituted benzamide derivative and a selective dopamine D2 antagonist with antipsychotic and antidepressant activity. Other benzamide derivatives include metoclopramide, tiapride, and sultopride.
Toxicity
Sulpiride has a relatively low order of acute toxicity. Substantial amounts may cause severe but reversible dystonic crises with torticollis, protrusion of the tongue, and/or trism. In some cases all the classical symptoms typical of severe Parkinson's Disease may be noted; in others, over-sedation/coma may occur.
Affected Organisms
Humans and other mammals
Absorption
Sulpiride is absorbed slowly from the gastrointestinal tract. Its oral bioavailability is only 25 to 35% with marked interindividual differences.
Half Life
6 to 8 hours
External Links
Molecular Spectra
No Data Available
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References
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