Substance
ID:270
Names and Identifiers
Brand Name
ElorineKemadrineProcyclidProcyklidinSpamolArpicolinTricoloidTricyclamolTriciloidMetaninOsnervanVagosinKemadrinLergineProsyklidinTriciclidina
Synonyms
Prociclidina [INN-Spanish]Procyclidinum [INN-Latin]Procyclidine
IUPAC name
1-cyclohexyl-1-phenyl-3-(pyrrolidin-1-yl)propan-1-ol
IUPAC Traditional name
procyclidine
Properties
Physical Property
Solubility
Moderately soluble in water, ~ 30 mg/ml
Hydrophobicity(logP)
4.2
Molecule Details
Drug Groups
approved
Description
A muscarinic antagonist that crosses the blood-brain barrier and is used in the treatment of drug-induced extrapyramidal disorders and in parkinsonism. [PubChem]
Indication
For the treatment of all forms of Parkinson's Disease, as well as control of extrapyramidal reactions induced by antipsychotic agents.
Pharmacology
Procyclidine has an atropine-like action on parasympathetic-innervated peripheral structures including smooth muscle. It's antispasmodic effects are thought to be related to the blockage of central cholinergic receptors M1, M2 and M4. It is used to treat symptomatic Parkinsonism and extrapyramidal dysfunction caused by antipsychotic agents.
Toxicity
LD50=60 mg/kg (IV in mice)
Affected Organisms
Humans and other mammals
Protein Binding
Approximately 100% bound to albumin.
References
•
Theodoridis GC, Stark L: Central role of solar information flow in pregenetic evolution. J Theor Biol. 1971 Jun;31(3):377-88.
[Pubmed]
External Links
Molecular Spectra
No Data Available
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References
• Theodoridis GC, Stark L: Central role of solar information flow in pregenetic evolution. J Theor Biol. 1971 Jun;31(3):377-88. Pubmed