Substance
ID:2219
Names and Identifiers
IUPAC name
(R)-[(5E,8E,11E,14E)-icosa-5,8,11,14-tetraen-1-yl](methoxy)phosphinoyl fluoride
Synonyms
MAFPMethoxy arachidonyl fluorophosphonate
IUPAC Traditional name
MAFP
Properties
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Molecule Details
Drug Groups
experimental
Description
Methoxy arachidonyl fluorophosphonate, commonly referred as MAFP, is an irreversible active site-directed enzyme inhibitor that inhibits nearly all serine hydrolases and serine proteases. It inhibits phospholipase A2 and fatty acid amide hydrolase with special potency, displaying IC50 values in the low-nanomolar range.
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Molecular Spectra
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References
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