Substance

ID:1866931

Names and Identifiers
IUPAC Traditional name
2-methoxy-N-[(2E)-3-[4-({3-methyl-4-[(6-methylpyridin-3-yl)oxy]phenyl}amino)quinazolin-6-yl]prop-2-en-1-yl]acetamide
Synonyms
CP-724714(E)-2-methoxy-N-[3-[4-[[3-methyl-4-[(6-methylpyridin-3-yl)oxy]phenyl]amino]quinazolin-6-yl]allyl]ethanamide2-methoxy-N-[(2E)-3-[4-[[3-methyl-4-[(6-methyl-3-pyridinyl)oxy]phenyl]amino]-6-quinazolinyl]-2-propen-1-yl]-acetamide2-methoxy-N-[(E)-3-[4-[3-methyl-4-(6-methylpyridin-3-yl)oxyanilino]quinazolin-6-yl]prop-2-enyl]acetamideCP 724714CP-724,714CP724714
IUPAC name
2-methoxy-N-[(2E)-3-[4-({3-methyl-4-[(6-methylpyridin-3-yl)oxy]phenyl}amino)quinazolin-6-yl]prop-2-en-1-yl]acetamide
Registration numbers
PubChem CID
9874913
CAS Number
845680-17-3
LINCS Database
LSM-42777
ACToR Database
845680-17-3
SureChEMBL Database
SCHEMBL95109
Chemspider ID
8,050,601
DrugBank ID
DB12302
BindingDB Database
31340
CHEBI ID
CHEBI:167658
PubChem SID
85366872
Properties
No Data Available
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Molecule Details
A 2-methoxy-N-[3-[4-[3-methyl-4-[(6-methyl-3-pyridinyl)oxy]anilino]-6-quinazolinyl]prop-2-enyl]acetamide in which the double bond adopts a trans-configuration. It is a potent inhibitor of HER2/ErbB2 (IC50 = 10 nM) and exhibits anti-cancer activity.
Molecular Spectra
No Data Available
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References
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