Drug Groups

approved

Description

Antibiotic analog of cloxacillin. [PubChem]

Indication

Used to treat bacterial infection by susceptible microorganisms.

Pharmacology

Flucloxacillin is a penicillin beta-lactam antibiotic used in the treatment of bacterial infections caused by susceptible, usually gram-positive, organisms. The name "penicillin" can either refer to several variants of penicillin available, or to the group of antibiotics derived from the penicillins. Flucloxacillin has in vitro activity against gram-positive and gram-negative aerobic and anaerobic bacteria. The bactericidal activity of Flucloxacillin results from the inhibition of cell wall synthesis and is mediated through flucloxacillin binding to penicillin binding proteins (PBPs). Flucloxacillin is stable against hydrolysis by a variety of beta-lactamases, including penicillinases, and cephalosporinases and extended spectrum beta-lactamases.

Affected Organisms

Biotransformation

Hepatic.

Absorption

Bioavailability is 50–70% following oral administration.

Half Life

0.75–1 hour

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