Substance
ID:1858114
Names and Identifiers
IUPAC Traditional name
plerixafor
Brand Name
Mozobil
IUPAC name
1-({4-[(1,4,8,11-tetraazacyclotetradecan-1-yl)methyl]phenyl}methyl)-1,4,8,11-tetraazacyclotetradecane
Synonyms
plerixafor1,1'-[1,4-phenylenebis(methylene)]bis(1,4,8,11-tetraazacyclotetradecane)1-[[4-(1,4,8,11-tetrazacyclotetradec-1-ylmethyl)phenyl]methyl]-1,4,8,11-tetrazacyclotetradecaneAMD 3100AMD-3100AMD3100JKL 169JM3100SDZ SID 791
International Nonproprietary Name (INN)
plerixaforplerixaforum
Registration numbers
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CHEMBL
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Properties
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Molecule Details
An azamacrocycle consisting of two cyclam rings connected by a 1,4-phenylenebis(methylene) linker. It is a CXCR4 chemokine receptor antagonist and a hematopoietic stem cell mobilizer. It is used in combination with grulocyte-colony stimulating factor (G-CSF) to mobilize hematopoietic stem cells to the perpheral blood for collection and subsequent autologous transplantation in patients with non-Hodgkin's lymphoma and multiple myeloma.
Molecular Spectra
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References
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