Substance
ID:184774
Names and Identifiers
Synonyms
对-[(2,4-二氨基喋啶-6)-N-甲基甲氨基]苯甲酰谷氨酸 水合物氟安定 水合物L-氨甲喋呤 水合物氨甲喋呤 水合物MTX 水合物氨甲叶酸 水合物甲氨蝶呤 水合物Methotrexate hydrate
IUPAC Traditional name
hydrate methotrexate
IUPAC name
(2S)-2-[(4-{[(2,4-diaminopteridin-6-yl)methyl](methyl)amino}phenyl)formamido]pentanedioic acid hydrate
Properties
Product Information
Suitability
suitable for insect cell culture
suitable for cell culture
Purity
≥98% (HPLC)
Physical Property
Apperance
powder
Solubility
H2O: insoluble
Safety Information
GHS Signal Word
Danger
Personal Protective Equipment
Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
GHS Pictograms
Acute toxicity (oral, dermal, inhalation), categories 1,2,3
Respiratory sensitization, category 1
Germ cell mutagenicity, categories 1A,1B,2
Carcinogenicity, categories 1A,1B,2
Reproductive toxicity, categories 1A,1B,2
Specific Target Organ Toxicity – Single exposure, categories 1,2
Specific Target Organ Toxicity – Repeated exposure, categories 1,2
Aspiration Hazard, category 1
RID/ADR
UN 1544 6.1/PG 3
Risk Statements
61-25-36/38
Hazard Class
6.1
UN Number
1544
Safety Statements
53-26-36/37-45
German water hazard class
3
European Hazard Symbols
Toxic (T)GHS Hazard statements
H301-H315-H319-H360
Storage Temperature
-20°C
Packing Group
3
GHS Precautionary statements
P201-P301+P310-P305+P351+P338-P308+P313
Molecule Details
Frequently Asked Questions
Live Chat and Frequently Asked Questions are available for this Product.
Application
Recommended for use in cell culture and molecular biology applications at 0.01-300 μM in nucleoside-free cell culture medium to select for DHFR expression.
Potent inhibitor of dihydrofolate reductase1 and agent for antitumor studies.2,3 Use to inhibit dihydrofolate reductase in DHFR-based protein expression systems. Also effective in treatment of pyrimethamine-resistant Plasmodium vivax malaria parasites.4
Potent inhibitor of dihydrofolate reductase1 and agent for antitumor studies.2,3 Use to inhibit dihydrofolate reductase in DHFR-based protein expression systems. Also shows immunosuppressive effects in, e.g., rheumatoid arthritis.
Biochem/physiol Actions
Methotrexate used to inhibit dihyrofolate reductase and select for DHFR overexpresssion.
Live Chat and Frequently Asked Questions are available for this Product.
Application
Recommended for use in cell culture and molecular biology applications at 0.01-300 μM in nucleoside-free cell culture medium to select for DHFR expression.
Potent inhibitor of dihydrofolate reductase1 and agent for antitumor studies.2,3 Use to inhibit dihydrofolate reductase in DHFR-based protein expression systems. Also effective in treatment of pyrimethamine-resistant Plasmodium vivax malaria parasites.4
Potent inhibitor of dihydrofolate reductase1 and agent for antitumor studies.2,3 Use to inhibit dihydrofolate reductase in DHFR-based protein expression systems. Also shows immunosuppressive effects in, e.g., rheumatoid arthritis.
Biochem/physiol Actions
Methotrexate used to inhibit dihyrofolate reductase and select for DHFR overexpresssion.
Molecular Spectra
No Data Available
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References
No Data Available
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