Substance
ID:184747
Names and Identifiers
Synonyms
(±)-N-Cyano-N′-4-pyridinyl-N″-(1,2,2-trimethylpropyl)guanidine monohydratePinacidil monohydrate
IUPAC name
(Z)-2-cyano-1-(3,3-dimethylbutan-2-yl)-3-(pyridin-4-yl)guanidine hydrate
IUPAC Traditional name
(Z)-2-cyano-1-(3,3-dimethylbutan-2-yl)-3-(pyridin-4-yl)guanidine hydrate
Properties
Physical Property
Solubility
DMSO: soluble15 mg/mL, clear
45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: soluble40 mg/mL
Apperance
white to beige powder
Safety Information
GHS Signal Word
Warning
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
GHS Precautionary statements
P261-P305+P351+P338
GHS Pictograms
Acute toxicity (oral, dermal, inhalation), category 4
Skin irritation, category 2
Eye irritation, category 2
Skin sensitisation, category 1
Specific Target Organ Toxicity – Single exposure, category 3
GHS Hazard statements
H302-H315-H319-H335
European Hazard Symbols
Harmful (Xn)German water hazard class
3
Risk Statements
22-36/37/38
Safety Statements
36
Pharmacology Properties
Gene Information
mouse ... Kcnj11(16514)rat ... Kcna1(24520), Kcnj1(24521), Kcnj11(83535), Kcnj5(29713), Kcnj8(25472)
Molecule Details
Biochem/physiol Actions
K+ channel activator; antihypertensive.
K+ channel activator; antihypertensive.
Molecular Spectra
No Data Available
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References
No Data Available
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