Substance
ID:184570
Names and Identifiers
IUPAC Traditional name
2-methoxyestradiol
Synonyms
1,3,5(10)-Estratriene-2,3,17-triol 2-methyl ether3,17β-Dihydroxy-2-methoxy-1,3,5(10)-estratriene2,3,17β-Trihydroxy-1,3,5(10)-estratriene 2-methyl ether2-Hydroxyestradiol 2-methyl ether2-Methoxyestradiol
IUPAC name
(1S,10R,11S,14S,15S)-4-methoxy-15-methyltetracyclo[8.7.0.02,7.011,15]heptadeca-2,4,6-triene-5,14-diol
Properties
Safety Information
GHS Precautionary statements
P201-P261-P280-P301+P310-P305+P351+P338-P311
RTECS
KG7537500
Personal Protective Equipment
Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
UN Number
3077
GHS Pictograms
Respiratory sensitization, category 1
Germ cell mutagenicity, categories 1A,1B,2
Carcinogenicity, categories 1A,1B,2
Reproductive toxicity, categories 1A,1B,2
Specific Target Organ Toxicity – Single exposure, categories 1,2
Specific Target Organ Toxicity – Repeated exposure, categories 1,2
Aspiration Hazard, category 1
Acute toxicity (oral, dermal, inhalation), categories 1,2,3
GHS Hazard statements
H301-H311-H315-H319-H331-H335-H350-H360-H372
RID/ADR
UN 3077 9/PG 3
Hazard Class
9
German water hazard class
3
GHS Signal Word
Danger
European Hazard Symbols
Toxic (T)Packing Group
3
Safety Statements
53-22-26-36/37/39-45
Risk Statements
45-46-60-61-23/24/25-36/37/38-48
Physical Property
Solubility
ethanol: soluble10 mg/mL
DMSO: soluble10 mg/mL
H2O: insoluble
Apperance
white to faint yellow powder
Pharmacology Properties
Gene Information
human ... ESR1(2099), ESR2(2100)
Molecule Details
Biochem/physiol Actions
2-Methoxyestradiol (2-ME) is a potent inhibitor of endothelial cell proliferation and angiogenesis. A major estradiol metabolite, it has little affinity for classical estrogen receptors.
Other Notes
Tandem Mass Spectrometry data independently generated by Scripps Center for Metabolomics is available to view or download in PDF. M6383.pdf Tested metabolites are featured on Scripps Center for Metabolomics METLIN Metabolite Database. To learn more, visit sigma.com/metlin.
2-Methoxyestradiol (2-ME) is a potent inhibitor of endothelial cell proliferation and angiogenesis. A major estradiol metabolite, it has little affinity for classical estrogen receptors.
Other Notes
Tandem Mass Spectrometry data independently generated by Scripps Center for Metabolomics is available to view or download in PDF. M6383.pdf Tested metabolites are featured on Scripps Center for Metabolomics METLIN Metabolite Database. To learn more, visit sigma.com/metlin.
Molecular Spectra
No Data Available
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References
No Data Available
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