Substance
ID:184514
Names and Identifiers
IUPAC name
3,5-diamino-N-(N-benzylcarbamimidoyl)-6-chloropyrazine-2-carboxamide hydrate hydrochloride
IUPAC Traditional name
3,5-diamino-N-(N-benzylcarbamimidoyl)-6-chloropyrazine-2-carboxamide hydrate hydrochloride
Synonyms
Benzamil hydrochloride hydrateN-(Benzylamidino)-3,5-diamino-6-chloropyrazinecarboxamide hydrochloride hydrate
Properties
Physical Property
Apperance
yellow solid
Solubility
methanol: soluble10 mg/mL
DMSO: >20 mg/mL
Safety Information
GHS Pictograms
Acute toxicity (oral, dermal, inhalation), category 4
Skin irritation, category 2
Eye irritation, category 2
Skin sensitisation, category 1
Specific Target Organ Toxicity – Single exposure, category 3
Safety Statements
26-36
Risk Statements
36/37/38
German water hazard class
3
GHS Signal Word
Warning
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Storage Temperature
2-8°C
GHS Precautionary statements
P261-P305+P351+P338
GHS Hazard statements
H315-H319-H335
European Hazard Symbols
Irritant (Xi)Pharmacology Properties
Gene Information
human ... SCNN1A(6337), SCNN1B(6338), SCNN1D(6339), SCNN1G(6340)mouse ... Scnn1a(20276), Scnn1b(20277), Scnn1d(140501), Scnn1g(20278)rat ... Scnn1a(25122), Scnn1b(24767), Scnn1g(24768)
Product Information
Purity
≥98% (HPLC)
Molecule Details
Biochem/physiol Actions
Selective and potent blocker of Na+/H+ and Na+/Ca2+ channels
Other Notes
Nω-Benzyl derivative of amiloride.
Selective and potent blocker of Na+/H+ and Na+/Ca2+ channels
Other Notes
Nω-Benzyl derivative of amiloride.
Molecular Spectra
No Data Available
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References
No Data Available
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