Substance
ID:184483
Names and Identifiers
IUPAC name
4-amino-N-(pyrimidin-2-yl)benzene-1-sulfonamide
IUPAC Traditional name
sulfadiazine
Synonyms
磺胺嘧啶SulfadiazineN-2-嘧啶基-4-氨基苯磺酰胺N1-(嘧啶-2-基)磺胺
Registration numbers
CAS Number
EC Number
Beilstein Number
MDL Number
PubChem SID
Properties
Product Information
Purity
≥99.0%
Suitability
suitable for 1694 per US EPA
Physical Property
Melting Point
253 °C (dec.)(lit.)
Safety Information
German water hazard class
3
RTECS
WP1925000
GHS Pictograms
Acute toxicity (oral, dermal, inhalation), category 4
Skin irritation, category 2
Eye irritation, category 2
Skin sensitisation, category 1
Specific Target Organ Toxicity – Single exposure, category 3
Respiratory sensitization, category 1
Germ cell mutagenicity, categories 1A,1B,2
Carcinogenicity, categories 1A,1B,2
Reproductive toxicity, categories 1A,1B,2
Specific Target Organ Toxicity – Single exposure, categories 1,2
Specific Target Organ Toxicity – Repeated exposure, categories 1,2
Aspiration Hazard, category 1
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
Safety Statements
26-36
European Hazard Symbols
Harmful (Xn)Risk Statements
22-36/37/38-42/43
GHS Precautionary statements
P261-P280-P305+P351+P338-P342+P311
GHS Signal Word
Danger
GHS Hazard statements
H302-H315-H317-H319-H334-H335
Molecule Details
包装
25, 50, 100, 250, 500 g in poly bottle
Application
Sulfadiazine is a short-acting sulfonamide that is commonly used with pyrimethamine to treat toxoplasmosis in patients with acquired immunodeficiency syndrome. It is also used to treat newborns with congenital infections1. Sulfadiazine has been used to control acute infections when studying murine models of reactivated toxoplasmosis2.
Biochem/physiol Actions
Sulfadiazine is a sulfonamide antibiotic that blocks the synthesis of dihydrofolic acid by inhibiting the enzyme dihydropteroate synthase. Sulfadiazine is a competitive inhibitor of bacterial para-aminobenzoic acid (PABA), which is required for bacterial synthesis of folic acid1. It is active against Gram positive bacteria, Gram negative bacteria and Chlamydia. Mode of resistance is via the alteration of dihydropteroate synthase or alternative pathway for folic acid synthesis.
25, 50, 100, 250, 500 g in poly bottle
Application
Sulfadiazine is a short-acting sulfonamide that is commonly used with pyrimethamine to treat toxoplasmosis in patients with acquired immunodeficiency syndrome. It is also used to treat newborns with congenital infections1. Sulfadiazine has been used to control acute infections when studying murine models of reactivated toxoplasmosis2.
Biochem/physiol Actions
Sulfadiazine is a sulfonamide antibiotic that blocks the synthesis of dihydrofolic acid by inhibiting the enzyme dihydropteroate synthase. Sulfadiazine is a competitive inhibitor of bacterial para-aminobenzoic acid (PABA), which is required for bacterial synthesis of folic acid1. It is active against Gram positive bacteria, Gram negative bacteria and Chlamydia. Mode of resistance is via the alteration of dihydropteroate synthase or alternative pathway for folic acid synthesis.
Molecular Spectra
No Data Available
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References
No Data Available
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