Substance
ID:184365
Names and Identifiers
Synonyms
CompactinML-236BMevastatin
IUPAC name
(1S,7S,8S,8aR)-8-{2-[(2R,4R)-4-hydroxy-6-oxooxan-2-yl]ethyl}-7-methyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl (2S)-2-methylbutanoate
IUPAC Traditional name
mevastatin
Registration numbers
CAS Number
Beilstein Number
MDL Number
PubChem SID
Properties
Safety Information
Storage Temperature
2-8°C
German water hazard class
3
Personal Protective Equipment
Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
Physical Property
Solubility
DMSO: soluble20 mg/mL
ethanol: soluble25 mg/mL
Apperance
white powder
Product Information
Purity
≥95% (HPLC)
Pharmacology Properties
Gene Information
human ... HMGCL(3155), HMGCR(3156)rat ... Hmgcr(25675)
Molecule Details
Biochem/physiol Actions
HMG-CoA reductase inhibitor. Cholesterol lowering drug. Inhibits myoblast formation. An antibiotic shown to cause apoptosis, apparently by inhibiting post-translational prenylation of proteins such as Ras. Similarly, mevastatin increases eNOS mRNA and protein levels by blocking the geranylgeranylation of Rho.
HMG-CoA reductase inhibitor. Cholesterol lowering drug. Inhibits myoblast formation. An antibiotic shown to cause apoptosis, apparently by inhibiting post-translational prenylation of proteins such as Ras. Similarly, mevastatin increases eNOS mRNA and protein levels by blocking the geranylgeranylation of Rho.
Molecular Spectra
No Data Available
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References
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