Substance
ID:184328
Names and Identifiers
Synonyms
SAM chloride dihydrochlorideActive methionineAdoMetS-(5′-Adenosyl)-L-methionine chloride dihydrochloride
IUPAC name
[(3S)-3-amino-3-carboxypropyl]({[(2S,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl})methylsulfanium chloride
IUPAC Traditional name
SAMe chloride
Registration numbers
Beilstein Number
CAS Number
EC Number
MDL Number
PubChem SID
Properties
Physical Property
Solubility
H2O: soluble100 mg/mL
Safety Information
German water hazard class
3
Storage Temperature
-20°C
Product Information
Purity
≥80%
Biological Source
from yeast (L-Methionine enriched)
Shipped in
dry ice
Molecule Details
Analysis Note
Purity based on UV and HPLC.
Caution
This material is 80-90% pure when prepared, but is very unstable. As much as 10% purity loss per day at 25 °C has been noted.
Biochem/physiol Actions
Methyl donor; cofactor for enzyme-catalyzed methylations, including catechol O-methyltransferase (COMT) and DNA methyltransferases (DNMT). Although present in all cells, it is concentrated in liver where 85% of all methylation reactions occur. It is also involved in regulating liver function, growth, and response to injury.
Purity based on UV and HPLC.
Caution
This material is 80-90% pure when prepared, but is very unstable. As much as 10% purity loss per day at 25 °C has been noted.
Biochem/physiol Actions
Methyl donor; cofactor for enzyme-catalyzed methylations, including catechol O-methyltransferase (COMT) and DNA methyltransferases (DNMT). Although present in all cells, it is concentrated in liver where 85% of all methylation reactions occur. It is also involved in regulating liver function, growth, and response to injury.
Molecular Spectra
No Data Available
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References
No Data Available
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