Substance
ID:184267
Names and Identifiers
IUPAC name
4-{4-[bis(2-chloroethyl)amino]phenyl}butanoic acid
Synonyms
4-[Bis(2-chloroethyl)amino]benzenebutyric acid4-(4-[Bis(2-chloroethyl)amino]phenyl)butyric acidChlorambucil
IUPAC Traditional name
chlorambucil
Registration numbers
CAS Number
Beilstein Number
EC Number
MDL Number
PubChem SID
Properties
Safety Information
RTECS
ES7525000
Personal Protective Equipment
Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
RID/ADR
UN 2811 6.1/PG 3
GHS Pictograms
Respiratory sensitization, category 1
Germ cell mutagenicity, categories 1A,1B,2
Carcinogenicity, categories 1A,1B,2
Reproductive toxicity, categories 1A,1B,2
Specific Target Organ Toxicity – Single exposure, categories 1,2
Specific Target Organ Toxicity – Repeated exposure, categories 1,2
Aspiration Hazard, category 1
Acute toxicity (oral, dermal, inhalation), categories 1,2,3
GHS Hazard statements
H301-H315-H319-H335-H350
GHS Precautionary statements
P201-P261-P301+P310-P305+P351+P338-P308+P313
Packing Group
3
GHS Signal Word
Danger
UN Number
2811
Risk Statements
45-25-36/37/38
Safety Statements
53-26-45
Hazard Class
6.1
European Hazard Symbols
Toxic (T)Storage Temperature
2-8°C
German water hazard class
3
Pharmacology Properties
Gene Information
human ... CYP2D6(1565)
Molecule Details
Biochem/physiol Actions
Chlorambucil is an anti-cancer drug that alkylates DNA and induces apoptosis. Death of chronic lymphocytic leukemia cells occurs via a p53-dependent mechanism.
Chlorambucil is an anti-cancer drug that alkylates DNA and induces apoptosis. Death of chronic lymphocytic leukemia cells occurs via a p53-dependent mechanism.
Molecular Spectra
No Data Available
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References
No Data Available
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