Substance
ID:184259
Names and Identifiers
IUPAC name
(3R,4S,5R)-3,4,5,6-tetrahydroxyhexanal
IUPAC Traditional name
deoxyglucose
Synonyms
2-脱氧-D-葡糖D-2-脱氧葡萄糖2-Deoxy-D-glucose
Registration numbers
CAS Number
EC Number
PubChem SID
MDL Number
Beilstein Number
Properties
Product Information
Cation Traces
Zn: ≤0.0005%
Cu: ≤0.0005%
Na: ≤0.005%
Ca: ≤0.003%
Fe: ≤0.0005%
K: ≤0.005%
Pb: ≤0.001%
NH4+: ≤0.05%
Al: ≤0.0005%
Mg: ≤0.0005%
Impurities
<0.1% Insoluble matter
≤0.001% Phosphorus (P)
Antion Traces
sulfate (SO42-): ≤0.05%
chloride (Cl-): ≤0.05%
Ignition Residue
<0.1%
Purity
≥98%
Safety Information
Personal Protective Equipment
Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
German water hazard class
3
Physical Property
Melting Point
146-147 °C(lit.)
Solubility
H2O: soluble1 M at 20 °C, clear, colorless
Molecule Details
Application
2-Deoxy-D-glucose is used in the development of anti-cancer strategies that involve radio- and chemosensitization and oxidative stress.
Biochem/physiol Actions
2-Deoxy-D-Glucose (2-Deoxyglucose) is a glucose analog that inhibits glycolysis via its actions on hexokinase, the rate limiting step of glycolysis. It is phosphorylated by hexokinase to 2-DG-P which can not be further metabolized by phosphoglucose isomerase. This leads to the accumulation of 2-DG-P in the cell and the depletion in cellular ATP. In vitro, 2-Deoxyglucose has been shown to induce autophagy, increase ROS production, and activate AMPK.1
2-Deoxy-D-glucose is used in the development of anti-cancer strategies that involve radio- and chemosensitization and oxidative stress.
Biochem/physiol Actions
2-Deoxy-D-Glucose (2-Deoxyglucose) is a glucose analog that inhibits glycolysis via its actions on hexokinase, the rate limiting step of glycolysis. It is phosphorylated by hexokinase to 2-DG-P which can not be further metabolized by phosphoglucose isomerase. This leads to the accumulation of 2-DG-P in the cell and the depletion in cellular ATP. In vitro, 2-Deoxyglucose has been shown to induce autophagy, increase ROS production, and activate AMPK.1
Molecular Spectra
No Data Available
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References
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