Substance
ID:184108
Names and Identifiers
IUPAC name
(1E,6E)-1,7-bis(4-hydroxy-3-methoxyphenyl)hepta-1,6-diene-3,5-dione
IUPAC Traditional name
curcumin
Synonyms
DiferulylmethaneCurcumin(E,E)-1,7-bis(4-Hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dioneDiferuloylmethaneNatural Yellow 3
Registration numbers
CAS Number
MDL Number
EC Number
Color Index Number
Beilstein Number
PubChem SID
Properties
Product Information
Purity
~70% (HPLC)
Biological Source
from Curcuma longa (Turmeric)
Physical Property
Apperance
orange powder
Vapor Density
13 (vs air)
Solubility
0.5 M NaOH: soluble (then immediately dilute in PBS)
ethanol: soluble10 mg/mL
DMSO: >11 mg/mL
Safety Information
GHS Signal Word
Warning
GHS Hazard statements
H315-H319-H335
GHS Precautionary statements
P261-P305+P351+P338
Risk Statements
36/37/38
RTECS
MI5230000
Storage Temperature
-20°C
Safety Statements
26
German water hazard class
3
GHS Pictograms
Acute toxicity (oral, dermal, inhalation), category 4
Skin irritation, category 2
Eye irritation, category 2
Skin sensitisation, category 1
Specific Target Organ Toxicity – Single exposure, category 3
European Hazard Symbols
Irritant (Xi)Pharmacology Properties
Gene Information
human ... APP(351), CYP1A2(1544)
Molecule Details
Biochem/physiol Actions
A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. Curcumin has been cited as a potential chemopreventive agent, in addition to its chemotherapeutic activity.1 Induces apoptosis in cancer cells and inhibits phorbol ester-induced protein kinase C (PKC) activity. Reported to inhibit production of inflammatory cytokines by peripheral blood monocytes and alveolar macrophages. Potent inhibitor of EGFR tyrosine kinase and IκB kinase. Inhibits inducible nitric oxide synthase (iNOS), cycloxygenase and lipoxygenase. Easily penetrates into the cytoplasm of cells, accumulating in membranous structures such as plasma membrane, endoplasmic reticulum and nuclear envelope.
A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. Curcumin has been cited as a potential chemopreventive agent, in addition to its chemotherapeutic activity.1 Induces apoptosis in cancer cells and inhibits phorbol ester-induced protein kinase C (PKC) activity. Reported to inhibit production of inflammatory cytokines by peripheral blood monocytes and alveolar macrophages. Potent inhibitor of EGFR tyrosine kinase and IκB kinase. Inhibits inducible nitric oxide synthase (iNOS), cycloxygenase and lipoxygenase. Easily penetrates into the cytoplasm of cells, accumulating in membranous structures such as plasma membrane, endoplasmic reticulum and nuclear envelope.
Molecular Spectra
No Data Available
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References
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