Substance
ID:183959
Names and Identifiers
Synonyms
(2S,3R,4R,6E)-2-Amino-3,4-dihydroxy-2-(hydroxymethyl)-14-oxo-6-eicosenoic acidMyriocin from Mycelia steriliaISP-IThermozymocidin
IUPAC name
(2S,3R,4R,6E)-2-amino-3,4-dihydroxy-2-(hydroxymethyl)-14-oxoicos-6-enoic acid
IUPAC Traditional name
myriocin
Properties
Physical Property
Apperance
off-white powder
Solubility
methanol: soluble2 mg/mL
Safety Information
European Hazard Symbols
Harmful (Xn)Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
RID/ADR
UN 2811 6.1/PG 3
GHS Hazard statements
H301
Storage Temperature
2-8°C
Risk Statements
22
RTECS
JX3890000
GHS Precautionary statements
P301+P310
GHS Signal Word
Danger
Packing Group
3
German water hazard class
3
GHS Pictograms
Acute toxicity (oral, dermal, inhalation), categories 1,2,3
Hazard Class
6.1
UN Number
2811
Product Information
Purity
≥98% (HPLC)
Molecule Details
Biochem/physiol Actions
Fungal metabolite with potent immunosuppressant activity. Inhibits serine palmitoyltransferase at picomolar concentrations blocking synthesis of ceramide, a precursor of sphingomyelin and glycosphingolipids. Disrupts substratum adhesion of melanoma cells. It has been suggested that its immunosuppressant activity in the cytotoxic T-cell line CTTL-2 is due to apoptosis induction.
Fungal metabolite with potent immunosuppressant activity. Inhibits serine palmitoyltransferase at picomolar concentrations blocking synthesis of ceramide, a precursor of sphingomyelin and glycosphingolipids. Disrupts substratum adhesion of melanoma cells. It has been suggested that its immunosuppressant activity in the cytotoxic T-cell line CTTL-2 is due to apoptosis induction.
Molecular Spectra
No Data Available
Click here to submit data
References
No Data Available
Click here to submit data