Substance
ID:183827
Names and Identifiers
IUPAC name
benzyl N-[(1S)-3-methyl-1-{[(1S)-3-methyl-1-{[(2S)-1-oxopentan-2-yl]carbamoyl}butyl]carbamoyl}butyl]carbamate
IUPAC Traditional name
benzyl N-[(1S)-3-methyl-1-{[(1S)-3-methyl-1-{[(2S)-1-oxopentan-2-yl]carbamoyl}butyl]carbamoyl}butyl]carbamate
Synonyms
Z-Leu-Leu-NorvalinalMG115Z-LLnV
Registration numbers
CAS Number
Properties
Pharmacology Properties
Gene Information
human ... PSMA1(5682), PSMC1(5700)mouse ... PSMA1(26440), PSMC1(19179)rat ... PSMA1(29668), PSMC1(117263)
Safety Information
Personal Protective Equipment
Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
German water hazard class
3
Storage Temperature
-20°C
Physical Property
Apperance
white powder
Solubility
DMSO: soluble
Product Information
Purity
≥90% (HPLC)
Molecule Details
Amino Acid Sequence
Z-Leu-Leu-Nva
Biochem/physiol Actions
Potent inhibitor of the 20S proteasome (Ki = 21 nM) and 26S proteasome (Ki = 35 nM). Cells treated with 54 μM N-CBZ-Leu-Leu-Norvalinal showed complete block of the G1/S and metaphase transitions and delayed passage through S-phase. Induces apoptosis in Rat-1 and PC12 cells, perhaps by accumulation of stabilized p53.
Z-Leu-Leu-Nva
Biochem/physiol Actions
Potent inhibitor of the 20S proteasome (Ki = 21 nM) and 26S proteasome (Ki = 35 nM). Cells treated with 54 μM N-CBZ-Leu-Leu-Norvalinal showed complete block of the G1/S and metaphase transitions and delayed passage through S-phase. Induces apoptosis in Rat-1 and PC12 cells, perhaps by accumulation of stabilized p53.
Molecular Spectra
No Data Available
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References
No Data Available
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