Substance
ID:183819
Names and Identifiers
IUPAC Traditional name
6-chloro-1,3-dihydropyrimidine-2,4-dione
IUPAC name
6-chloro-1,2,3,4-tetrahydropyrimidine-2,4-dione
Synonyms
4-Chloro-2,6-dihydroxypyrimidine6-Chloro-2,4-dihydroxypyrimidine6-Chlorouracil4-Chlorouracil
Properties
Safety Information
Safety Statements
26-36
Risk Statements
36/37/38
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
European Hazard Symbols
Irritant (Xi)GHS Precautionary statements
P261-P305+P351+P338
GHS Signal Word
Warning
GHS Pictograms
Acute toxicity (oral, dermal, inhalation), category 4
Skin irritation, category 2
Eye irritation, category 2
Skin sensitisation, category 1
Specific Target Organ Toxicity – Single exposure, category 3
German water hazard class
3
GHS Hazard statements
H315-H319-H335
Product Information
Purity
≥99%
Molecule Details
Application
Chlorouracil (4-Chlorouracil; 6-Chlorouracil) is a halogenated uracil that is useful in studies of the effects of halogenation on nucleic acid base-pair stability and alkali metal ion affinity.Reaction of 6-chlorouracil with 4-(dimethylamino)pyridine, 4-methylpyridine, and pyridin-4-yl-morpholine yielded pyridinium-substituted uracils as chlorides which were converted into pyridinium uracilates by deprotonation. These heterocyclic mesomeric betaines are cross-conjugated and thus possess separate cationic (pyridinium) and anionic (uracilate) moieties. Calculations and X-ray single crystal analyses may be used to characterize these systems and to compare the salts with the betaines.
Chlorouracil (4-Chlorouracil; 6-Chlorouracil) is a halogenated uracil that is useful in studies of the effects of halogenation on nucleic acid base-pair stability and alkali metal ion affinity.Reaction of 6-chlorouracil with 4-(dimethylamino)pyridine, 4-methylpyridine, and pyridin-4-yl-morpholine yielded pyridinium-substituted uracils as chlorides which were converted into pyridinium uracilates by deprotonation. These heterocyclic mesomeric betaines are cross-conjugated and thus possess separate cationic (pyridinium) and anionic (uracilate) moieties. Calculations and X-ray single crystal analyses may be used to characterize these systems and to compare the salts with the betaines.
Molecular Spectra
No Data Available
Click here to submit data
References
No Data Available
Click here to submit data