Substance
ID:183626
Names and Identifiers
IUPAC Traditional name
sulfachloropyridazine
IUPAC name
4-amino-N-(6-chloropyridazin-3-yl)benzene-1-sulfonamide
Synonyms
磺胺氯哒嗪Sulfachloropyridazine4-氨基-N-(6-氯-3-哒嗪基)苯磺酰胺
Registration numbers
MDL Number
PubChem SID
Beilstein Number
CAS Number
EC Number
Properties
Safety Information
German water hazard class
3
European Hazard Symbols
Irritant (Xi)Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
GHS Precautionary statements
P280
GHS Hazard statements
H317
GHS Pictograms
Acute toxicity (oral, dermal, inhalation), category 4
Skin irritation, category 2
Eye irritation, category 2
Skin sensitisation, category 1
Specific Target Organ Toxicity – Single exposure, category 3
GHS Signal Word
Warning
Risk Statements
43
Safety Statements
36/37
Product Information
Suitability
suitable for 1694 per US EPA
Molecule Details
Application
Sulfachloropyridazine is a sulfonamide antibiotic that is used to study kinetics, reaction pathways and toxicity evolution1. Sulfachloropyridazine has been used to treat acute urinary tract infections in pediatric patients2.
Biochem/physiol Actions
Sulfachloropyridazine is a sulfonamide antibiotic that blocks the synthesis of dihydrofolic acid by inhibiting the enzyme dihydropteroate synthase. Sulfachloropyridazine is a competitive inhibitor of bacterial para-aminobenzoic acid (PABA), which is required for bacterial synthesis of folic acid3. It is active against Gram positive bacteria, Gram negative bacteria and Chlamydia. Mode of resistance is via the alteration of dihydropteroate synthase or alternative pathway for folic acid synthesis. Sulfachloropyridazine is rapidly absorbed and rapidly excreted in the urine4.
Sulfachloropyridazine is a sulfonamide antibiotic that is used to study kinetics, reaction pathways and toxicity evolution1. Sulfachloropyridazine has been used to treat acute urinary tract infections in pediatric patients2.
Biochem/physiol Actions
Sulfachloropyridazine is a sulfonamide antibiotic that blocks the synthesis of dihydrofolic acid by inhibiting the enzyme dihydropteroate synthase. Sulfachloropyridazine is a competitive inhibitor of bacterial para-aminobenzoic acid (PABA), which is required for bacterial synthesis of folic acid3. It is active against Gram positive bacteria, Gram negative bacteria and Chlamydia. Mode of resistance is via the alteration of dihydropteroate synthase or alternative pathway for folic acid synthesis. Sulfachloropyridazine is rapidly absorbed and rapidly excreted in the urine4.
Molecular Spectra
No Data Available
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References
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