Substance
ID:183595
Names and Identifiers
IUPAC Traditional name
wortmannin
IUPAC name
(1R,3R,5S,9R,18S)-18-(methoxymethyl)-1,5-dimethyl-6,11,16-trioxo-13,17-dioxapentacyclo[10.6.1.02,10.05,9.015,19]nonadeca-2(10),12(19),14-trien-3-yl acetate
Synonyms
KY 12420Wortmannin
Registration numbers
PubChem SID
CAS Number
Beilstein Number
MDL Number
Properties
Product Information
Quality Level
PREMIUM
Purity
≥98% (HPLC and TLC)
Biological Source
from Penicillium funiculosum
Physical Property
Solubility
H2O: unstable
DMSO: soluble
Apperance
off-white powder
Safety Information
GHS Pictograms
Acute toxicity (oral, dermal, inhalation), categories 1,2,3
Hazard Class
6.1
UN Number
3462
GHS Hazard statements
H300-H310-H330
European Hazard Symbols
Highly toxic (T+)RID/ADR
UN 3462 6.1/PG 1
Safety Statements
28-36/37-45
Packing Group
1
Risk Statements
26/27/28
Storage Temperature
2-8°C
GHS Signal Word
Danger
German water hazard class
3
Personal Protective Equipment
Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
GHS Precautionary statements
P260-P264-P280-P284-P302+P350-P310
RTECS
CB9641000
Pharmacology Properties
Gene Information
human ... PIK3CD(5293), PIK3CG(5294), PIK3R1(5295)
Molecule Details
Biochem/physiol Actions
Wortmannin is a potent and specific phosphatidylinositol 3-kinase (PI3-K) inhibitor with an IC50 of 2-4 nM. Inhibition of PI3-K/Akt signal transduction cascade enhances the apoptotic effects of radiation or serum withdrawal and blocks the antiapoptotic effect of cytokines. Inhibition of PI3-K by wortmannin also blocks many of the short-term metabolic effects induced by insulin receptor activation.
Wortmannin is a potent and specific phosphatidylinositol 3-kinase (PI3-K) inhibitor with an IC50 of 2-4 nM. Inhibition of PI3-K/Akt signal transduction cascade enhances the apoptotic effects of radiation or serum withdrawal and blocks the antiapoptotic effect of cytokines. Inhibition of PI3-K by wortmannin also blocks many of the short-term metabolic effects induced by insulin receptor activation.
Molecular Spectra
No Data Available
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References
No Data Available
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