Substance
ID:183522
Names and Identifiers
Synonyms
(S)-(-)-Propranolol hydrochloride(S)-(-)-普奈洛尔 盐酸盐(S)-1-异丙基氨基-3-(1-萘氧基)-2-丙醇 盐酸盐
IUPAC name
[(2S)-2-hydroxy-3-(naphthalen-1-yloxy)propyl](propan-2-yl)amine hydrochloride
IUPAC Traditional name
[(2S)-2-hydroxy-3-(naphthalen-1-yloxy)propyl](isopropyl)amine hydrochloride
Registration numbers
EC Number
MDL Number
PubChem SID
CAS Number
Beilstein Number
Properties
Safety Information
German water hazard class
3
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
GHS Signal Word
Warning
Risk Statements
20/21/22
GHS Hazard statements
H302-H312-H332
European Hazard Symbols
Harmful (Xn)GHS Precautionary statements
P280
Safety Statements
36
GHS Pictograms
Acute toxicity (oral, dermal, inhalation), category 4
Skin irritation, category 2
Eye irritation, category 2
Skin sensitisation, category 1
Specific Target Organ Toxicity – Single exposure, category 3
Storage Temperature
2-8°C
Physical Property
Optical Rotation
[α]25/D -25.5°, c = 1.0 in ethanol(lit.)
Solubility
45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: soluble8.0 mg/mL
H2O: soluble50 mg/mL (With heat. Aqueous solutions are most stable at pH 3.0 and decompose rapidly at basic pH. Decomposition is accompanied by discoloration of the solution.)
DMSO: <14.5 mg/mL
ethanol: soluble10 mg/mL
Melting Point
193-195 °C(lit.)
Apperance
powder
Pharmacology Properties
Gene Information
human ... ADRB1(153), ADRB2(154), ADRB3(155), HTR1A(3350), HTR1B(3351), HTR1D(3352), HTR1E(3354), HTR1F(3355)
Product Information
Purity
≥98% (TLC)
Molecule Details
包装
100, 500 mg in glass bottle
Biochem/physiol Actions
Active β-adrenoceptor blocking enantiomer, as measured by inhibition of isoprenaline-induced tachycardia; Propranolol is also non-specific 5-HT1A, 5-HT1B and 5-HT1C serotonin receptor antagonist. The stereoselective association of mianserin and propranolol with the 5HT1A, 5HT1B and 5HT1C sites may prove useful in the characterization of these sites
100, 500 mg in glass bottle
Biochem/physiol Actions
Active β-adrenoceptor blocking enantiomer, as measured by inhibition of isoprenaline-induced tachycardia; Propranolol is also non-specific 5-HT1A, 5-HT1B and 5-HT1C serotonin receptor antagonist. The stereoselective association of mianserin and propranolol with the 5HT1A, 5HT1B and 5HT1C sites may prove useful in the characterization of these sites
Molecular Spectra
No Data Available
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References
No Data Available
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