Substance
ID:183473
Names and Identifiers
IUPAC Traditional name
sodium cefalotin(1-)
IUPAC name
sodium (6R,7R)-3-[(acetyloxy)methyl]-8-oxo-7-[2-(thiophen-2-yl)acetamido]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
Synonyms
Cephalothin sodium salt7-(2-Thienylacetamido)cephalosporanic acid sodium saltCephalotin sodium salt
Registration numbers
EC Number
MDL Number
Beilstein Number
CAS Number
PubChem SID
Properties
Safety Information
GHS Signal Word
Danger
GHS Hazard statements
H317-H334
GHS Precautionary statements
P261-P280-P342+P311
GHS Pictograms
Respiratory sensitization, category 1
Germ cell mutagenicity, categories 1A,1B,2
Carcinogenicity, categories 1A,1B,2
Reproductive toxicity, categories 1A,1B,2
Specific Target Organ Toxicity – Single exposure, categories 1,2
Specific Target Organ Toxicity – Repeated exposure, categories 1,2
Aspiration Hazard, category 1
Safety Statements
22-36/37
European Hazard Symbols
Harmful (Xn)RTECS
XI0388300
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
Risk Statements
42/43
German water hazard class
2
Storage Temperature
2-8°C
Product Information
Purity
96.0-101.0%
Molecule Details
Biochem/physiol Actions
Cephalothin is a first-generation cephalosporin antibiotic that disrupts the synthesis of the peptidoglycan layer of bacterial cell walls. It is effective against gram-positive and gram-negative bacteria. Mode of Resistance: Cephalosporinase production.
Mode of Action: Inhibits cell wall synthesis.Antimicrobial spectrum: Gram-positive cocci.Mode of Resistance: Cephalosporinase production.
Other Notes
First generation cephalosporin antibiotic.
Application
Cephalothis is used to study the mechanism of liposome encapsulated antibiotics 1, strategies for co-opting β-lactamases of Gram-negative bacteria for treatment of antibiotics 2, and for immunology studies in relation to antibiotics 3. It is used to study the effect of expression, binding and inhibition of penicillin-binding proteins especially PBP6 on bacterial cell wall mucopeptide synthesis.
Protocols & Applications
Antibiotic Selector for application, solubility, solution stability, working concentration, and mode of action information
Cephalothin is a first-generation cephalosporin antibiotic that disrupts the synthesis of the peptidoglycan layer of bacterial cell walls. It is effective against gram-positive and gram-negative bacteria. Mode of Resistance: Cephalosporinase production.
Mode of Action: Inhibits cell wall synthesis.Antimicrobial spectrum: Gram-positive cocci.Mode of Resistance: Cephalosporinase production.
Other Notes
First generation cephalosporin antibiotic.
Application
Cephalothis is used to study the mechanism of liposome encapsulated antibiotics 1, strategies for co-opting β-lactamases of Gram-negative bacteria for treatment of antibiotics 2, and for immunology studies in relation to antibiotics 3. It is used to study the effect of expression, binding and inhibition of penicillin-binding proteins especially PBP6 on bacterial cell wall mucopeptide synthesis.
Protocols & Applications
Antibiotic Selector for application, solubility, solution stability, working concentration, and mode of action information
Molecular Spectra
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References
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