Substance
ID:183452
Names and Identifiers
IUPAC Traditional name
platinum(II) chloride diamine
IUPAC name
dichloroplatinum diamine
Synonyms
顺式-二胺二氯铂顺-二氯二氨基铂(II)顺氯氨铂cis-Diammineplatinum(II) dichloride顺铂
Properties
Physical Property
Melting Point
270 °C(lit.)
Apperance
yellow crystalline
Safety Information
GHS Pictograms
Acute toxicity (oral, dermal, inhalation), categories 1,2,3
Respiratory sensitization, category 1
Germ cell mutagenicity, categories 1A,1B,2
Carcinogenicity, categories 1A,1B,2
Reproductive toxicity, categories 1A,1B,2
Specific Target Organ Toxicity – Single exposure, categories 1,2
Specific Target Organ Toxicity – Repeated exposure, categories 1,2
Aspiration Hazard, category 1
Corrosive to metals, category 1
Skin corrosion, categories 1A,1B,1C
Serious eye damage, category 1
GHS Precautionary statements
P201-P264-P280-P301+P310-P305+P351+P338-P308+P313
RTECS
TP2450000
Safety Statements
53-26-39-45
Hazard Class
6.1
GHS Signal Word
Danger
GHS Hazard statements
H300-H318-H350
German water hazard class
3
Packing Group
2
RID/ADR
UN 3288 6.1/PG 2
European Hazard Symbols
Toxic (T)Risk Statements
45-25-41
UN Number
3288
Molecule Details
Frequently Asked Questions
Live Chat and Frequently Asked Questions are available for this Product.
Biochem/physiol Actions
强效的铂基抗肿瘤剂。与 DNA 二核苷酸 d(pGpG) 形成细胞毒性加合物，诱导链内交联。
Potent chemoimmunotherapeutic drug; stimulates the immune responses by activating macrophages and other cells of the immune system. Cisplatin-treated macrophages show increased antigen presentation function in vitro. Treatment increased cellular NF-κB content and translocation in macrophages. Cisplatin effects are regulated by kinases, phosphatases, and Ca2+/calmodulin. Forms cytotoxic adducts with the DNA dinucleotide d(pGpG), inducing intrastrand crosslinks.
包装
1 g in glass bottle
25, 100, 250 mg in glass bottle
Live Chat and Frequently Asked Questions are available for this Product.
Biochem/physiol Actions
强效的铂基抗肿瘤剂。与 DNA 二核苷酸 d(pGpG) 形成细胞毒性加合物，诱导链内交联。
Potent chemoimmunotherapeutic drug; stimulates the immune responses by activating macrophages and other cells of the immune system. Cisplatin-treated macrophages show increased antigen presentation function in vitro. Treatment increased cellular NF-κB content and translocation in macrophages. Cisplatin effects are regulated by kinases, phosphatases, and Ca2+/calmodulin. Forms cytotoxic adducts with the DNA dinucleotide d(pGpG), inducing intrastrand crosslinks.
包装
1 g in glass bottle
25, 100, 250 mg in glass bottle
Molecular Spectra
No Data Available
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References
No Data Available
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