Substance
ID:183432
Names and Identifiers
IUPAC name
3,5,7-trihydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-one
IUPAC Traditional name
kaempferol
Synonyms
Robigenin3,4′,5,7-Tetrahydroxyflavone3,5,7-Trihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-oneKaempferol
Registration numbers
Beilstein Number
MDL Number
PubChem SID
CAS Number
Properties
Safety Information
Storage Condition
protect from light
GHS Pictograms
Acute toxicity (oral, dermal, inhalation), categories 1,2,3
Respiratory sensitization, category 1
Germ cell mutagenicity, categories 1A,1B,2
Carcinogenicity, categories 1A,1B,2
Reproductive toxicity, categories 1A,1B,2
Specific Target Organ Toxicity – Single exposure, categories 1,2
Specific Target Organ Toxicity – Repeated exposure, categories 1,2
Aspiration Hazard, category 1
GHS Signal Word
Danger
European Hazard Symbols
Toxic (T)Risk Statements
25-68
Safety Statements
36/37-45
Storage Temperature
room temp
GHS Precautionary statements
P281-P301+P310
GHS Hazard statements
H301-H341
Personal Protective Equipment
Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
German water hazard class
3
Physical Property
Solubility
ethanol: soluble20 mg/mL
DMSO: soluble50 mg/mL
Apperance
yellow powder
Pharmacology Properties
Gene Information
human ... CDC2(983), CDK5(1020), CDK6(1021), CYP1A2(1544), CYP2C9(1559), GSK3A(2931)mouse ... Hexa(15211)
Product Information
Purity
≥90% (HPLC)
Molecule Details
Application
Chromogenic reagent for antimony in the low ppm range2 and for gallium and indium in the sub-ppm range.3
Biochem/physiol Actions
A flavonol shown to revert the transformed phenotype of phorbol ester-treated mouse fibroblasts or v-H-ras-transformed NIH 3T3 cells. Induces significant nuclear DNA degradation concurrent with lipid peroxidation.4 Inhibits topoisomerase I catalyzed DNA religation.5 Kaempferol may also inhibit the activity of fatty acid synthase.
Potent inhibitor of osteoclastic bone resorption. The effect is believed to be attributable to both the antioxidant and estrogenic activities of kaempferol.1
Chromogenic reagent for antimony in the low ppm range2 and for gallium and indium in the sub-ppm range.3
Biochem/physiol Actions
A flavonol shown to revert the transformed phenotype of phorbol ester-treated mouse fibroblasts or v-H-ras-transformed NIH 3T3 cells. Induces significant nuclear DNA degradation concurrent with lipid peroxidation.4 Inhibits topoisomerase I catalyzed DNA religation.5 Kaempferol may also inhibit the activity of fatty acid synthase.
Potent inhibitor of osteoclastic bone resorption. The effect is believed to be attributable to both the antioxidant and estrogenic activities of kaempferol.1
Molecular Spectra
No Data Available
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References
No Data Available
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