Substance
ID:183422
Names and Identifiers
IUPAC Traditional name
dexamethasone
Synonyms
德沙美松地塞米松9α-氟-16α-甲基氢化泼尼松Dexamethasone21α-乙酰氧基-9α-氟-11β,17α-二羟基-16α-甲基孕甾-1,4-二烯-3,20-二酮9-氟-11,17,21-三羟基-16-甲基(11b,16a)-孕甾-1,4-二烯-3,20-二酮
IUPAC name
(1R,2S,10S,11S,13R,14R,15S,17S)-1-fluoro-14,17-dihydroxy-14-(2-hydroxyacetyl)-2,13,15-trimethyltetracyclo[8.7.0.02,7.011,15]heptadeca-3,6-dien-5-one
Registration numbers
EC Number
Beilstein Number
MDL Number
CAS Number
PubChem SID
Properties
Product Information
Potency
4-500 ng/mL
Purity
≥80% (HPLC)
Suitability
suitable for cell culture
Sterility
γ-irradiated
Physical Property
Melting Point
262-264 °C(lit.)
Apperance
powder
Pharmacology Properties
Gene Information
human ... ABCB1(5243), CYP3A4(1576), IL4(3565), IL5(3567), NR3C1(2908)mouse ... Abcb1a(18671), Abcb1b(18669), Ifng(15978), Nos2(18126), Ptgs2(19225), Tnf(21926)rat ... Ar(24208), Nr3c1(24413), Tnf(24835)
Safety Information
GHS Signal Word
Danger
GHS Pictograms
Respiratory sensitization, category 1
Germ cell mutagenicity, categories 1A,1B,2
Carcinogenicity, categories 1A,1B,2
Reproductive toxicity, categories 1A,1B,2
Specific Target Organ Toxicity – Single exposure, categories 1,2
Specific Target Organ Toxicity – Repeated exposure, categories 1,2
Aspiration Hazard, category 1
Acute toxicity (oral, dermal, inhalation), category 4
Skin irritation, category 2
Eye irritation, category 2
Skin sensitisation, category 1
Specific Target Organ Toxicity – Single exposure, category 3
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
RTECS
TU3980000
German water hazard class
2
GHS Hazard statements
H315-H317-H319-H334-H335
Safety Statements
22-26-36/37-45
Risk Statements
36/37/38-42/43
European Hazard Symbols
Harmful (Xn)GHS Precautionary statements
P261-P280-P305+P351+P338-P342+P311
Storage Temperature
2-8°C
Molecule Details
Frequently Asked Questions
Live Chat and Frequently Asked Questions are available for this Product.
Application
一种抗炎糖皮质素，对细胞存活、细胞信号传导和基因表达具有一系列的影响。用于研究细胞凋亡、细胞信号传导通路和基因表达。
Reconstitution
要制备 20μg/ml 储备液：加入 1ml 无水乙醇，缓缓搅拌溶解，加入 49ml 无菌培养基。
Physical form
2-8°C 下为粉末状，分成小份冻存以避免使用时反复冷冻/解冻。
Biochem/physiol Actions
糖皮质素抗炎剂。调控 T 细胞的存活、生长和分化。抑制一氧化氮合酶的诱导作用。
Live Chat and Frequently Asked Questions are available for this Product.
Application
一种抗炎糖皮质素，对细胞存活、细胞信号传导和基因表达具有一系列的影响。用于研究细胞凋亡、细胞信号传导通路和基因表达。
Reconstitution
要制备 20μg/ml 储备液：加入 1ml 无水乙醇，缓缓搅拌溶解，加入 49ml 无菌培养基。
Physical form
2-8°C 下为粉末状，分成小份冻存以避免使用时反复冷冻/解冻。
Biochem/physiol Actions
糖皮质素抗炎剂。调控 T 细胞的存活、生长和分化。抑制一氧化氮合酶的诱导作用。
Molecular Spectra
No Data Available
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References
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