Substance
ID:183157
Names and Identifiers
IUPAC Traditional name
dicoumarol
IUPAC name
4-hydroxy-3-[(4-hydroxy-2-oxo-2H-chromen-3-yl)methyl]-2H-chromen-2-one
Synonyms
3,3′-Methylene-bis(4-hydroxycoumarin)DicumarolDicoumarol
Properties
Safety Information
GHS Pictograms
Hazardous to the aquatic environment
Acute hazard, category1
Chronic hazard, categories 1,2
Respiratory sensitization, category 1
Germ cell mutagenicity, categories 1A,1B,2
Carcinogenicity, categories 1A,1B,2
Reproductive toxicity, categories 1A,1B,2
Specific Target Organ Toxicity – Single exposure, categories 1,2
Specific Target Organ Toxicity – Repeated exposure, categories 1,2
Aspiration Hazard, category 1
Acute toxicity (oral, dermal, inhalation), category 4
Skin irritation, category 2
Eye irritation, category 2
Skin sensitisation, category 1
Specific Target Organ Toxicity – Single exposure, category 3
European Hazard Symbols
Nature polluting (N)
Toxic (T)GHS Precautionary statements
P273-P314
Risk Statements
22-48/25-51/53
GHS Hazard statements
H302-H372-H411
Personal Protective Equipment
Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
RTECS
GN7875000
RID/ADR
UN 2811 6.1/PG 3
UN Number
2811
GHS Signal Word
Danger
Hazard Class
6.1
Packing Group
3
German water hazard class
3
Safety Statements
37-45-61
Pharmacology Properties
Gene Information
human ... CYP2C9(1559)
Physical Property
Melting Point
290-292 °C(lit.)
Molecule Details
Biochem/physiol Actions
Prototype of the 4-hydroxycoumarin class of anticoagulants, which act as vitamin K antagonists, preventing formation of prothrombin. There are many reports that dicumarol also inhibits NADPH:quinone oxidoreductase (NQO(1)). In one1, it inhibited NQO(1) in a pancreatic cancer cell line, causing increased formation of superoxide and inhibiting cell growth.
Prototype of the 4-hydroxycoumarin class of anticoagulants, which act as vitamin K antagonists, preventing formation of prothrombin. There are many reports that dicumarol also inhibits NADPH:quinone oxidoreductase (NQO(1)). In one1, it inhibited NQO(1) in a pancreatic cancer cell line, causing increased formation of superoxide and inhibiting cell growth.
Molecular Spectra
No Data Available
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References
No Data Available
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