Substance
ID:183143
Names and Identifiers
Synonyms
Phytosphingosine hydrochlorideD-Ribo-2-aminooctadecane-1,3,4-triolPHSD-Ribo-1,3,4-trihydroxy-2-aminooctadecane4-Hydroxysphinganine
IUPAC name
(2S,3S,4R)-2-aminooctadecane-1,3,4-triol hydrochloride
IUPAC Traditional name
phytosphingosine hydrochloride
Properties
Safety Information
Personal Protective Equipment
Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
Storage Temperature
-20°C
German water hazard class
1
Product Information
Biological Source
from Saccharomyces cerevisiae
Purity
~97%
Molecule Details
Biochem/physiol Actions
Phytosphingosine is a long chain sphingoid base that occurs broadly in yeast, plants and animals including mammals. In yeast it is involved in mediating the heat stress response, perhaps through activation of the AGC-type protein kinases, Pkh1, Pkh2, Ypk1, Ypk2, and Sch9. It is proapoptotic in human cancer cell lines. PHS induces ΔΨm and release of cytochrome c from mitochondria either directly or through activation of p38 MAPK pathway. This leads to activation of caspase 9 followed by activation of caspase 3 and programmed cell death.
Phytosphingosine is a long chain sphingoid base that occurs broadly in yeast, plants and animals including mammals. In yeast it is involved in mediating the heat stress response, perhaps through activation of the AGC-type protein kinases, Pkh1, Pkh2, Ypk1, Ypk2, and Sch9. It is proapoptotic in human cancer cell lines. PHS induces ΔΨm and release of cytochrome c from mitochondria either directly or through activation of p38 MAPK pathway. This leads to activation of caspase 9 followed by activation of caspase 3 and programmed cell death.
Molecular Spectra
No Data Available
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References
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