Substance
ID:183081
Names and Identifiers
IUPAC name
1-{1-[4,4-bis(4-fluorophenyl)butyl]piperidin-4-yl}-2,3-dihydro-1H-1,3-benzodiazol-2-one
IUPAC Traditional name
pimozide
Synonyms
1-[1-[4,4-Bis(4-fluorophenyl)butyl]-4-piperidinyl]-1,3-dihydro-2H-benzimidazol-2-onePimozide
Properties
Physical Property
Solubility
H2O: insoluble
DMSO: soluble18 mg/mL
Safety Information
Risk Statements
22
GHS Hazard statements
H302
Storage Temperature
2-8°C
German water hazard class
3
Safety Statements
36
GHS Pictograms
Acute toxicity (oral, dermal, inhalation), category 4
Skin irritation, category 2
Eye irritation, category 2
Skin sensitisation, category 1
Specific Target Organ Toxicity – Single exposure, category 3
GHS Signal Word
Warning
European Hazard Symbols
Harmful (Xn)Pharmacology Properties
Gene Information
human ... ABCB1(5243), CACNA1G(8913), CYP3A4(1576), DRD2(1813), HTR7(3363), KCNH1(3756), KCNH2(3757), OPRD1(4985)mouse ... Abcb1a(18671), Abcb1b(18669)rat ... Scnn1g(24768)
Molecule Details
Biochem/physiol Actions
D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7 receptor; Ca2+ channel antagonist; antipsychotic
D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7 receptor; Ca2+ channel antagonist; antipsychotic
Molecular Spectra
No Data Available
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References
No Data Available
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