Substance
ID:182973
Names and Identifiers
Synonyms
Doxepin hydrochloride多虑平 盐酸盐11-(3-Dimethylaminopropylidene)-6,11-dihydrodibenz[b,e]oxepine hydrochloride
IUPAC Traditional name
dimethyl({3-[(2E)-9-oxatricyclo[9.4.0.03,8]pentadeca-1(15),3(8),4,6,11,13-hexaen-2-ylidene]propyl})amine hydrochloride
IUPAC name
dimethyl({3-[(2E)-9-oxatricyclo[9.4.0.03,8]pentadeca-1(15),3(8),4,6,11,13-hexaen-2-ylidene]propyl})amine hydrochloride
Properties
Safety Information
GHS Hazard statements
H301
European Hazard Symbols
Toxic (T)RID/ADR
UN 2811 6.1/PG 3
RTECS
HQ4375000
Hazard Class
6.1
Risk Statements
25
GHS Signal Word
Danger
Personal Protective Equipment
Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
Packing Group
3
GHS Pictograms
Acute toxicity (oral, dermal, inhalation), categories 1,2,3
GHS Precautionary statements
P301+P310
Safety Statements
36/37/39-45
UN Number
2811
German water hazard class
3
Product Information
Purity
≥98% (GC)
15% Z-isomer basis
~85% E-isomer basis
Physical Property
Apperance
white to off-white powder
Solubility
1 M HCl: soluble50 mg/mL
H2O: soluble
Pharmacology Properties
Gene Information
human ... ADRA1A(148), ADRA1B(147), ADRA1D(146), CHRM1(1128), CHRM2(1129), CHRM3(1131), CHRM4(1132), CHRM5(1133), HRH1(3269), HTR1A(3350), HTR1B(3351), HTR1D(3352), HTR1E(3354), HTR1F(3355), HTR2A(3356), HTR2B(3357), HTR2C(3358), HTR3A(3359), HTR3B(9177), HTR3C(170572), HTR3D(200909), HTR3E(285242), HTR4(3360), HTR5A(3361), HTR5B(645694), HTR6(3362), HTR7(3363)
Molecule Details
Other Notes
Mixture of cis- and trans-isomers
Biochem/physiol Actions
Tricyclic antidepressant that is a more potent inhibitor of norepinephrine uptake than of serotonin uptake; antagonist at H1 histamine, muscarinic cholinergic, and α-adrenoreceptors.
Mixture of cis- and trans-isomers
Biochem/physiol Actions
Tricyclic antidepressant that is a more potent inhibitor of norepinephrine uptake than of serotonin uptake; antagonist at H1 histamine, muscarinic cholinergic, and α-adrenoreceptors.
Molecular Spectra
No Data Available
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References
No Data Available
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