Substance
ID:182877
Names and Identifiers
IUPAC name
1-(6-{[(1S,10R,11S,14S,15S)-5-methoxy-15-methyltetracyclo[8.7.0.02,7.011,15]heptadeca-2,4,6-trien-14-yl]amino}hexyl)-2,5-dihydro-1H-pyrrole-2,5-dione hydrate
Synonyms
U-73122 hydrate1-[6-[((17β)-3-Methoxyestra-1,3,5[10]-trien-17-yl)amino]hexyl]-1H-pyrrole-2,5-dione
IUPAC Traditional name
1-(6-{[(1S,10R,11S,14S,15S)-5-methoxy-15-methyltetracyclo[8.7.0.02,7.011,15]heptadeca-2,4,6-trien-14-yl]amino}hexyl)pyrrole-2,5-dione hydrate
Properties
Safety Information
GHS Hazard statements
H315-H319-H335
Safety Statements
26-36
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Storage Temperature
room temp
GHS Signal Word
Warning
Risk Statements
36/37/38
European Hazard Symbols
Irritant (Xi)GHS Precautionary statements
P261-P305+P351+P338
GHS Pictograms
Acute toxicity (oral, dermal, inhalation), category 4
Skin irritation, category 2
Eye irritation, category 2
Skin sensitisation, category 1
Specific Target Organ Toxicity – Single exposure, category 3
German water hazard class
3
Physical Property
Solubility
H2O: insoluble
ethanol: ~.7 mg/mL
DMSO: ≤2.6 mg/mL (Achieved with heating.)
DMSO: ~.9 mg/mL
chloroform: ~10 mg/mL
ethanol: ≤5 mg/mL (Achieved with heating.)
Apperance
off-white powder
Molecule Details
Biochem/physiol Actions
Inhibits the hydrolysis of PPI to IP3, which leads to a decrease in cytosolic free calcium. Inhibits the coupling of G protein-phospholipase C activation, while remaining unaffected by production of cAMP.
Inhibits the hydrolysis of PPI to IP3, which leads to a decrease in cytosolic free calcium. Inhibits the coupling of G protein-phospholipase C activation, while remaining unaffected by production of cAMP.
Molecular Spectra
No Data Available
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References
No Data Available
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