Substance
ID:182768
Names and Identifiers
IUPAC name
3-(2-chloroethyl)-1-(4-methylcyclohexyl)-3-nitrosourea
Synonyms
司莫司汀SemustineMethyl-CCNUN-(2-氯乙基)-N′-(4-甲基环己基)-N-亚硝脲
IUPAC Traditional name
semustine
Properties
Safety Information
GHS Signal Word
Danger
RID/ADR
UN 2811 6.1/PG 2
Risk Statements
45-46-23/24/25-36/37/38
Safety Statements
53-22-26-36/37/39-45
UN Number
2811
GHS Pictograms
Acute toxicity (oral, dermal, inhalation), categories 1,2,3
Respiratory sensitization, category 1
Germ cell mutagenicity, categories 1A,1B,2
Carcinogenicity, categories 1A,1B,2
Reproductive toxicity, categories 1A,1B,2
Specific Target Organ Toxicity – Single exposure, categories 1,2
Specific Target Organ Toxicity – Repeated exposure, categories 1,2
Aspiration Hazard, category 1
European Hazard Symbols
Toxic (T)GHS Precautionary statements
P201-P261-P264-P280-P301+P310-P305+P351+P338
RTECS
YS5000000
GHS Hazard statements
H300-H311-H315-H319-H331-H335-H350-H360
Hazard Class
6.1
Personal Protective Equipment
Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
Packing Group
2
German water hazard class
3
Molecule Details
Application
Commonly used in pharmacological studies involving:
• Nutrient-sensitized screening for drugs that shift the energy metabolism from mitchondrial respiration to glycolysis1
• CEOP regimen with semustine used as induction chemotherapy in patients with lymphoma2
• Investigations into its use for chemotherapy3,4
Commonly used in pharmacological studies involving:
• Nutrient-sensitized screening for drugs that shift the energy metabolism from mitchondrial respiration to glycolysis1
• CEOP regimen with semustine used as induction chemotherapy in patients with lymphoma2
• Investigations into its use for chemotherapy3,4
Molecular Spectra
No Data Available
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References
No Data Available
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