Substance
ID:182738
Names and Identifiers
IUPAC name
5-(1,2-dithiolan-3-yl)pentanoic acid
IUPAC Traditional name
6,8-thioctic acid
Synonyms
Lip(S2)6,8-二巯基辛酸DL-α-硫辛酸(±)-α-硫辛酸DL-6,8-硫辛酸(±)-α-Lipoic acid(±)-1,2-二硫戊环基-3-戊酸
Registration numbers
Beilstein Number
EC Number
PubChem SID
CAS Number
MDL Number
Properties
Product Information
Biological Source
synthetic
Description
Oxidized form
Purity
≥99% (titration)
Safety Information
Risk Statements
22
GHS Hazard statements
H302
RTECS
JP1192000
GHS Signal Word
Warning
GHS Pictograms
Acute toxicity (oral, dermal, inhalation), category 4
Skin irritation, category 2
Eye irritation, category 2
Skin sensitisation, category 1
Specific Target Organ Toxicity – Single exposure, category 3
European Hazard Symbols
Harmful (Xn)German water hazard class
3
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Pharmacology Properties
Gene Information
human ... ACHE(43), BCHE(590)rat ... Adra1a(29412), Adra1b(24173), Adra1d(29413)
Physical Property
Apperance
yellow powder
Solubility
ethanol: soluble50 mg/mL
Molecule Details
包装
1, 5, 25, 50 g in poly bottle
500 mg in poly bottle
Biochem/physiol Actions
维持酶复合物（例如丙酮酸脱氢酶和甘氨酸脱羧酶的复合物）活性所需的抗氧化剂和辅酶。通过两种或多种酶的作用在细胞内还原外源性硫辛酸。然后，该还原形式通过直接清除自由基、循环利用其他抗氧化剂、增加谷胱甘肽的合成以及调控转录因子（尤其是 NF-κB）的活性而影响许多细胞过程。减少巨噬细胞对髓磷脂的吞噬。
1, 5, 25, 50 g in poly bottle
500 mg in poly bottle
Biochem/physiol Actions
维持酶复合物（例如丙酮酸脱氢酶和甘氨酸脱羧酶的复合物）活性所需的抗氧化剂和辅酶。通过两种或多种酶的作用在细胞内还原外源性硫辛酸。然后，该还原形式通过直接清除自由基、循环利用其他抗氧化剂、增加谷胱甘肽的合成以及调控转录因子（尤其是 NF-κB）的活性而影响许多细胞过程。减少巨噬细胞对髓磷脂的吞噬。
Molecular Spectra
No Data Available
Click here to submit data
References
No Data Available
Click here to submit data