Substance
ID:182737
Names and Identifiers
IUPAC name
5-(1,2-dithiolan-3-yl)pentanoic acid
IUPAC Traditional name
6,8-thioctic acid
Synonyms
Lip(S2)6,8-二巯基辛酸DL-α-硫辛酸(±)-α-硫辛酸DL-6,8-硫辛酸(±)-α-Lipoic acid(±)-1,2-二硫戊环基-3-戊酸
Registration numbers
Beilstein Number
EC Number
CAS Number
MDL Number
PubChem SID
Properties
Physical Property
Solubility
ethanol: soluble50 mg/mL
Product Information
Purity
≥99%
Suitability
cell culture tested
Safety Information
German water hazard class
3
GHS Pictograms
Acute toxicity (oral, dermal, inhalation), category 4
Skin irritation, category 2
Eye irritation, category 2
Skin sensitisation, category 1
Specific Target Organ Toxicity – Single exposure, category 3
European Hazard Symbols
Harmful (Xn)GHS Hazard statements
H302
RTECS
JP1192000
GHS Signal Word
Warning
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Risk Statements
22
Pharmacology Properties
Gene Information
human ... ACHE(43), BCHE(590)rat ... Adra1a(29412), Adra1b(24173), Adra1d(29413)
Molecule Details
Other Notes
氧化形式
Biochem/physiol Actions
维持酶复合物（例如丙酮酸脱氢酶和甘氨酸脱羧酶的复合物）活性所需的抗氧化剂和辅酶。通过两种或多种酶的作用在细胞内还原外源性硫辛酸。然后，该还原形式通过直接清除自由基、循环利用其他抗氧化剂、增加谷胱甘肽的合成以及调控转录因子（尤其是 NF-κB）的活性而影响许多细胞过程。减少巨噬细胞对髓磷脂的吞噬。
氧化形式
Biochem/physiol Actions
维持酶复合物（例如丙酮酸脱氢酶和甘氨酸脱羧酶的复合物）活性所需的抗氧化剂和辅酶。通过两种或多种酶的作用在细胞内还原外源性硫辛酸。然后，该还原形式通过直接清除自由基、循环利用其他抗氧化剂、增加谷胱甘肽的合成以及调控转录因子（尤其是 NF-κB）的活性而影响许多细胞过程。减少巨噬细胞对髓磷脂的吞噬。
Molecular Spectra
No Data Available
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References
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