Substance
ID:182660
Names and Identifiers
IUPAC name
3-methyl-3-nitroso-1-[(2S,3R,4R,5S,6R)-2,4,5-trihydroxy-6-(hydroxymethyl)oxan-3-yl]urea
IUPAC Traditional name
streptozocin
Synonyms
StreptozocinN-(Methylnitrosocarbamoyl)-α-D-glucosamineStreptozotocin
Registration numbers
CAS Number
Beilstein Number
EC Number
MDL Number
PubChem SID
Properties
Physical Property
Apperance
white to off-white powder
Melting Point
121 °C (dec.)(lit.)
Safety Information
Safety Statements
53-45
GHS Hazard statements
H350
Personal Protective Equipment
Eyeshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
Risk Statements
45
GHS Pictograms
Respiratory sensitization, category 1
Germ cell mutagenicity, categories 1A,1B,2
Carcinogenicity, categories 1A,1B,2
Reproductive toxicity, categories 1A,1B,2
Specific Target Organ Toxicity – Single exposure, categories 1,2
Specific Target Organ Toxicity – Repeated exposure, categories 1,2
Aspiration Hazard, category 1
Storage Temperature
-20°C
European Hazard Symbols
Toxic (T)RTECS
LZ5775000
German water hazard class
3
GHS Signal Word
Danger
GHS Precautionary statements
P201-P308+P313
Product Information
Purity
≥98% (HPLC)
≥75% α-anomer basis
Molecule Details
Frequently Asked Questions
Live Chat and Frequently Asked Questions are available for this Product.
Application
Streptozocin is used to induce Type 1 diabetes for medical research.
General description
Streptozotocin, a glucosamine-nitrosourea, is a DNA alkylating agent that enters cells exclusively via the GLUT2 glucose transport protein. Streptozocin, a diabetagen, is especially toxic to pancreatic islet insulin-producing β-cells. It is toxic to GLUT2 positive neuroendocrine tumor cells.
Other Notes
Mixed anomers
包装
1, 5 g in glass bottle
100, 500 mg in glass bottle
50 mg in poly bottle
Biochem/physiol Actions
An N-nitroso-containing compound that acts as a nitric oxide donor in pancreatic islets; induces death of insulin-secreting cells, producing an animal model of diabetes. Potent DNA methylating agent that induces chromosomal breakage.1 Cytotoxic to neuroendocrine tumor cell lines that express the GLUT2 glucose transporter.
Live Chat and Frequently Asked Questions are available for this Product.
Application
Streptozocin is used to induce Type 1 diabetes for medical research.
General description
Streptozotocin, a glucosamine-nitrosourea, is a DNA alkylating agent that enters cells exclusively via the GLUT2 glucose transport protein. Streptozocin, a diabetagen, is especially toxic to pancreatic islet insulin-producing β-cells. It is toxic to GLUT2 positive neuroendocrine tumor cells.
Other Notes
Mixed anomers
包装
1, 5 g in glass bottle
100, 500 mg in glass bottle
50 mg in poly bottle
Biochem/physiol Actions
An N-nitroso-containing compound that acts as a nitric oxide donor in pancreatic islets; induces death of insulin-secreting cells, producing an animal model of diabetes. Potent DNA methylating agent that induces chromosomal breakage.1 Cytotoxic to neuroendocrine tumor cell lines that express the GLUT2 glucose transporter.
Molecular Spectra
No Data Available
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References
No Data Available
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