Substance

ID:1826506

Names and Identifiers
Synonyms
SN-3810-Hydroxy-7-ethylcamptothecin7-Ethyl-10-hydroxy-20(S)-camptothecin7-Ethyl-10-hydroxycamptothecinNK 012NK-012SN 38SN 38 lactoneSN-38
IUPAC name
(19S)-10,19-diethyl-7,19-dihydroxy-17-oxa-3,13-diazapentacyclo[11.8.0.0²,¹¹.0⁴,⁹.0¹⁵,²⁰]henicosa-1(21),2,4,6,8,10,15(20)-heptaene-14,18-dione
IUPAC Traditional name
(19S)-10,19-diethyl-7,19-dihydroxy-17-oxa-3,13-diazapentacyclo[11.8.0.0^{2,11}.0^{4,9}.0^{15,20}]henicosa-1(21),2,4,6,8,10,15(20)-heptaene-14,18-dione
Registration numbers
CAS Number
86639-52-3
Wikipedia Title
SN-38
PubChem CID
104842
KEGG ID
C11173
Reaxys Registry
4829984
ACToR Database
113015-38-686639-52-3
BKMS React Database
159265
BRENDA Database
3.1.1.1
BRENDA Ligand Database
159265
CHEMBL
CHEMBL837
CompTox Database
DTXSID4040399
Protein Data Bank
6vxj
SureChEMBL Database
SCHEMBL34018
Rhea Database
RHEA:63696
HMDB Database
HMDB0060510
PDBeChem Database
RS4
ArrayExpress (Gene Expression Altlas)
E-MEXP-1194
CHEBI ID
CHEBI:8988
PubChem SID
223440911
Properties
No Data Available
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Molecule Details
A member of the class of pyranoindolizinoquinolines that is (4S)-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14-dione bearing two additional ethyl substituents at positions 4 and 11 as well as two additional hydroxy substituents at positions 4 and 9. It is the active metabolite of irinotecan and is ~1000 times more active than irinotecan itself.
Molecular Spectra
No Data Available
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References
No Data Available
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